Nerve terminal currents at lizard neuromuscular junction (Lindgren, Moore 1989)

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Accession:10360
Loose patch clamp measurement of presynaptic ionic currents at lizard neuromuscular junction compared with computer simulations.
Reference:
1 . Lindgren CA, Moore JW (1989) Identification of ionic currents at presynaptic nerve endings of the lizard. J Physiol 414:201-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuromuscular Junction;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  I Na,t; I K;
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lindgren89
README
ending.ses
fig13.ses
init.hoc
mosinit.hoc
                            
Lindgren and Moore. (1989) Identification of ionic currents at
presynaptic nerve terminal of the lizard.
J. Physiol. 414: 201-222

Experimental observations of ionic currents localized in the presynaptic
terminal region were made with a focal loose-patch clamp.  In addition
to finding Hodgkin-Huxley (HH) type sodium and potassium currents an L
type calcium channel and a calcium-activated potassium channel were
identified. 

Computer simulations matching the invasion of the action potential
(figure 2) and the major current patterns (figure 1) were able to be
generated, using only the Na and K channels of HH

The NEURON implementation of this model was prepared by Michael Hines. 
Questions about details of this implementation should be addressed to
him at michael.hines@yale.edu. 



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