Modulation of septo-hippocampal theta activity by GABAA receptors (Hajos et al. 2004)

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Accession:116567
Theta frequency oscillation of the septo-hippocampal system has been considered as a prominent activity associated with cognitive function and affective processes. ... In the present experiments we applied a combination of computational and physiological techniques to explore the functional role of GABAA receptors in theta oscillation. ... In parallel to these experimental observations, a computational model has been constructed by implementing a septal GABA neuron model with a CA1 hippocampal model containing three types of neurons (including oriens and basket interneurons and pyramidal cells; latter modeled by multicompartmental techniques; for detailed model description with network parameters see online addendum: http://geza.kzoo.edu/theta). This connectivity made the network capable of simulating the responses of the septo-hippocampal circuitry to the modulation of GABAA transmission, and the presently described computational model proved suitable to reveal several aspects of pharmacological modulation of GABAA receptors. In addition, computational findings indicated different roles of distinctively located GABAA receptors in theta generation.
Reference:
1 . Hajós M, Hoffmann WE, Orbán G, Kiss T, Erdi P (2004) Modulation of septo-hippocampal Theta activity by GABAA receptors: an experimental and computational approach. Neuroscience 126:599-610 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 interneuron oriens alveus GABA cell; Hippocampus CA1 basket cell;
Channel(s): I Na,t; I A; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 interneuron oriens alveus GABA cell; GabaA; I Na,t; I A; I K; I M; I h; I K,Ca; I Calcium;
//genesis

//*****************************************************************************
//... es lon a kornek kerulete
float	PI		=	3.14159

//*****************************************************************************
//integralasi idok adjusztalasa

//*****************************************************************************
//Az egyszeruseg es elegancia kedveert:
int	EXPONENTIAL	=	1
int	SIGMOID		=	2
int	LINOID		=	3

//*****************************************************************************
///Remelheto, hogy ekkora egy sejt ...
float	SOMA_D_OLM	=	20.0e-6				// m
float	SOMA_L_OLM	=	20.0e-6				// m
float	SOMA_A_OLM	=	PI * SOMA_D_OLM * SOMA_L_OLM	// m^2
float	SOMA_XA_OLM	=	PI * SOMA_D_OLM * SOMA_D_OLM / 4	// m^2

//*****************************************************************************
//Tovabbi szukseges konstansok
//MEMBRANE PARAMETERS
float	RM_OLM		=	1		// ohm*m^2
float	RA_OLM		=	0.3		// ohm-m
float	CM_OLM		=	0.01		// F/m^2
float	EREST_ACT_OLM	=	-65e-3		// V

//*****************************************************************************
//A tablazatokhoz

float	VRES		=	3200
float	VMIN		=	-0.100		// V
float	VMAX		=	0.110		// V

//*****************************************************************************
//A misztikus PHI parameter
float	Phi		=	5

//Szinapszis kuszob fesz.
float Theta = 0
float Theta_m2o = 0

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