"... In this work, we used computer modeling of
quanta release kinetics with various levels of calcium influx
and in the presence of endogenous calcium buffers with
varying mobilities.
The results of this modeling revealed
the desynchronization of quanta release under low calcium
influx in the presence of an endogenous fixed calcium
buffer, with a diffusion coefficient much smaller than that
of free Ca2+, and synchronization occurred upon adding a
mobile buffer. This corresponds to changes in secretion
time course parameters found experimentally ..."
Reference:
1 .
Gilmanov IR, Samigullin DV, Vyskocil F, Nikolsky EE, Bukharaeva EA (2008) Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers. J Comput Neurosci 25:296-307 [PubMed]
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