ModelDB: Roles of I(A) and morphology in AP prop. in CA1 pyramidal cell dendrites (Acker and White 2007)

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Roles of I(A) and morphology in AP prop. in CA1 pyramidal cell dendrites (Acker and White 2007)

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Accession:118014

" ...Using conductance-based models of CA1 pyramidal cells, we show that underlying “traveling wave attractors” control action potential propagation in the apical dendrites. By computing these attractors, we dissect and quantify the effects of IA channels and dendritic morphology on bAP amplitudes. We find that non-uniform activation properties of IA can lead to backpropagation failure similar to that observed experimentally in these cells. ... "
Reference:
1 . Acker CD, White JA (2007) Roles of IA and morphology in action potential propagation in CA1 pyramidal cell dendrites. J Comput Neurosci 23:201-16 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	XPPAUT;
Model Concept(s):	Active Dendrites; Influence of Dendritic Geometry; Action Potentials;
Implementer(s):	Acker, Corey [acker at uchc.edu];

Search NeuronDB for information about: Hippocampus CA1 pyramidal GLU cell; I Na,t; I A; I K;

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