New and corrected simulations of synaptic facilitation (Matveev et al. 2002)

Help downloading and running models
"A three-dimensional presynaptic calcium diffusion model developed to account for characteristics of transmitter release was modified to provide for binding of calcium to a receptor and subsequent triggering of exocytosis. When low affinity (20 FLM) and rapid kinetics were assumed for the calcium receptor triggering exocytosis, and stimulus parameters were selected to match those of experiments, the simulations predicted a virtual invariance of the time course of transmitter release to paired stimulation, stimulation with pulses of different amplitude, and stimulation in different calcium solutions. ..."
1 . Matveev V, Sherman A, Zucker RS (2002) New and corrected simulations of synaptic facilitation. Biophys J 83:1368-73 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network;
Brain Region(s)/Organism:
Cell Type(s):
Gap Junctions:
Simulation Environment: CalC Calcium Calculator (web link to model);
Model Concept(s): Facilitation; Calcium dynamics;
Implementer(s): Matveev, Victor V. [m a t v e e v at n j i t . e d u ];
(located via links below)
Loading data, please wait...