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Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
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Accession:
119266
"We use a multi-compartmental model of a CA1 pyramidal cell to study changes in hippocampal excitability that result from aging-induced alterations in calcium-dependent membrane mechanisms. The model incorporates N- and L-type calcium channels which are respectively coupled to fast and slow afterhyperpolarization potassium channels. Model parameters are calibrated using physiological data. Computer simulations reproduce the decreased excitability of aged CA1 cells, which results from increased internal calcium accumulation, subsequently larger postburst slow afterhyperpolarization, and enhanced spike frequency adaptation. We find that aging-induced alterations in CA1 excitability can be modelled with simple coupling mechanisms that selectively link specific types of calcium channels to specific calcium-dependent potassium channels."
Reference:
1 .
Markaki M, Orphanoudakis S, Poirazi P (2005) Modelling reduced excitability in aged CA1 neurons as a calcium-dependent process
Neurocomputing
65-66
:305-314
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I N;
I A;
I K;
I M;
I K,Ca;
I R;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Aging/Alzheimer`s;
Implementer(s):
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I N
;
I A
;
I K
;
I M
;
I K,Ca
;
I R
;
Download the displayed file
/
CA1_Aged
lib
basic_graphics.hoc
*
Other models using basic_graphics.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
basic-graphics.hoc
*
Other models using basic-graphics.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Fast Spiking Basket cells (Tzilivaki et al 2019)
L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
choose-secs.hoc
*
Other models using choose-secs.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
current-balance.hoc
cut-sections.hoc
*
Other models using cut-sections.hoc:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
deduce-ratio.hoc
*
Other models using deduce-ratio.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
find-gmax.hoc
*
Other models using find-gmax.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
GABA_shiftsyn.hoc
*
Other models using GABA_shiftsyn.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
GABA_shiftsyn_bg.hoc
*
Other models using GABA_shiftsyn_bg.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
ken.h
*
Other models using ken.h:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
map-segments-to-3d.hoc
*
Other models using map-segments-to-3d.hoc:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
maxmin.hoc
*
Other models using maxmin.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
mod_func.c
*
Other models using mod_func.c:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
newshiftsyn
*
Other models using newshiftsyn:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
newshiftsyn.c
*
Other models using newshiftsyn.c:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
num-rec.h
*
Other models using num-rec.h:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
salloc.hoc
*
Other models using salloc.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
shiftsyn-init_bg.hoc
*
Other models using shiftsyn-init_bg.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
shiftsyn-initA.hoc
*
Other models using shiftsyn-initA.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
spikecount.hoc
*
Other models using spikecount.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
tune-epsps.hoc
*
Other models using tune-epsps.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
vector-distance.hoc
*
Other models using vector-distance.hoc:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
verbose-system.hoc
*
Other models using verbose-system.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
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