ModelDB: Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)

Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)

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Accession:119283

In this paper, the model was used to show how neuroactive drugs targeting different neuronal mechanisms affect the signal integration in CA1 pyramidal neuron. Ferrante M, Blackwell KT, Migliore M, Ascoli GA (2008)
Reference:
1 . Ferrante M, Blackwell KT, Migliore M, Ascoli GA (2008) Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets. Curr Med Chem 15:2456-71 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	NEURON;
Model Concept(s):	Action Potential Initiation; Action Potentials; Pathophysiology; Epilepsy; Synaptic Integration; Parkinson's; Aging/Alzheimer`s; Schizophrenia; Spike Frequency Adaptation;
Implementer(s):	Ferrante, Michele [mferr133 at bu.edu];