ModelDB: Membrane potential changes in dendritic spines during APs and synaptic input (Palmer & Stuart 2009)

Membrane potential changes in dendritic spines during APs and synaptic input (Palmer & Stuart 2009)

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Accession:120798

" ... Finally, we used simulations of our experimental observations in morphologically realistic models to estimate spine neck resistance. These simulations indicated that spine neck resistance ranges up to ~500 M Ohm. Spine neck resistances of this magnitude reduce somatic EPSPs by ~15%, indicating that the spine neck is unlikely to act as a physical device to significantly modify synaptic strength."
Reference:
1 . Palmer LM, Stuart GJ (2009) Membrane potential changes in dendritic spines during action potentials and synaptic input. J Neurosci 29:6897-903 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
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Simulation Environment:	NEURON;
Model Concept(s):	Active Dendrites; Influence of Dendritic Geometry; Synaptic Integration;
Implementer(s):	Morse, Tom [Tom.Morse at Yale.edu]; Stuart, Greg J. [greg.stuart at anu.edu.au];