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Membrane potential changes in dendritic spines during APs and synaptic input (Palmer & Stuart 2009)
 
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Accession:
120798
" ... Finally, we used simulations of our experimental observations in morphologically realistic models to estimate spine neck resistance. These simulations indicated that spine neck resistance ranges up to ~500 M Ohm. Spine neck resistances of this magnitude reduce somatic EPSPs by ~15%, indicating that the spine neck is unlikely to act as a physical device to significantly modify synaptic strength."
Reference:
1 .
Palmer LM, Stuart GJ (2009) Membrane potential changes in dendritic spines during action potentials and synaptic input.
J Neurosci
29
:6897-903
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Active Dendrites;
Influence of Dendritic Geometry;
Synaptic Integration;
Implementer(s):
Morse, Tom [Tom.Morse at Yale.edu];
Stuart, Greg J. [greg.stuart at anu.edu.au];
Download the displayed file
/
PalmerStuart2009
readme.html
syn_g.mod
fig5.hoc
fig5b.jpg
fig5cd.jpg
iclamp_supfig2.ses
insert_synapses.hoc
mosinit.hoc
Ri18geometry.hoc
Ri18init_passive.hoc
run_cntrl.ses
runRi18.hoc
soma_spine_v_graph.ses
suplfig2c.jpg
suppl_fig2c.hoc
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Fig. 5
Fig. 5B
Suppl. Fig. 2 c
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