Electrically-coupled Retzius neurons (Vazquez et al. 2009)

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"Dendritic electrical coupling increases the number of effective synaptic inputs onto neurons by allowing the direct spread of synaptic potentials from one neuron to another. Here we studied the summation of excitatory postsynaptic potentials (EPSPs) produced locally and arriving from the coupled neuron (transjunctional) in pairs of electrically-coupled Retzius neurons of the leech. We combined paired recordings of EPSPs, the production of artificial EPSPs (APSPs) in neuron pairs with different coupling coefficients and simulations of EPSPs produced in the coupled dendrites. ..."
1 . Vazquez Y, Mendez B, Trueta C, De-Miguel FF (2009) Summation of excitatory postsynaptic potentials in electrically-coupled neurones. Neuroscience 163:202-12 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech Retzius neuron;
Channel(s): I Na,t; I A; I K; I K,Ca; I Calcium;
Gap Junctions: Gap junctions;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration;
Search NeuronDB for information about:  I Na,t; I A; I K; I K,Ca; I Calcium;
TITLE gkcadend.mod   
UNITS {          
   (uM) = (micro/liter)          
   (mM) = (milli/liter)          
   (mA) = (milliamp)          
   (mV) = (millivolt)   
NEURON {          
   SUFFIX gkcadend         
   USEION ca READ cai      
   USEION k READ ek WRITE ik          
   RANGE gkcabar, ikca
   GLOBAL cinf, cexp

INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) }          
PARAMETER {          
   celsius (degC)
   dt (ms)
   v (mV) 
   gkcabar = 0.013(mho/cm2)    
   ikca (ma/cm2)
ASSIGNED {          
   ik  (mA/cm2)          
   cai (mM)          
   cinf cexp

LOCAL tinc, q10, alpha, beta, sum

BREAKPOINT {          
        q10 = 3^((celsius - 20)/10)
        tinc = -dt * q10
        alpha = 0.1 * (cai / 0.01)
        beta =  0.1
        sum = alpha + beta
        cinf = alpha/sum
        cexp = 1 - exp(tinc*sum)
        c = c + cexp*(cinf-c)
        ikca = gkcabar * c * (v-ek)
        ik = ikca

        alpha = 0.1 * (cai / 0.01)
        beta =  0.1 
        sum = alpha + beta
        cinf = alpha/sum
        c = cinf     

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