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Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
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Accession:
123815
This NEURON code implements a small network model (100 pyramidal cells and 4 types of inhibitory interneuron) of storage and recall of patterns in the CA1 region of the mammalian hippocampus. Patterns of PC activity are stored either by a predefined weight matrix generated by Hebbian learning, or by STDP at CA3 Schaffer collateral AMPA synapses.
Reference:
1 .
Cutsuridis V, Cobb S, Graham BP (2010) Encoding and retrieval in a model of the hippocampal CA1 microcircuit.
Hippocampus
20
:423-46
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Hippocampus CA1 basket cell;
Channel(s):
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Pattern Recognition;
Activity Patterns;
Temporal Pattern Generation;
Learning;
STDP;
Connectivity matrix;
Storage/recall;
Implementer(s):
Graham, Bruce [B.Graham at cs.stir.ac.uk];
Cutsuridis, Vassilis [vcutsuridis at gmail.com];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
GabaA
;
AMPA
;
NMDA
;
/
Hipp_paper_code
Results
Weights
readme.txt
ANsyn.mod
*
Other models using ANsyn.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Signal integration in a CA1 pyramidal cell (Graham 2001)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
bgka.mod
*
Other models using bgka.mod:
Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
burststim2.mod
*
Other models using burststim2.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
cad.mod
*
Other models using cad.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
cagk.mod
*
Other models using cagk.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
cal.mod
*
Other models using cal.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
calH.mod
*
Other models using calH.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
car.mod
*
Other models using car.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
cat.mod
*
Other models using cat.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
ccanl.mod
*
Other models using ccanl.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
gskch.mod
*
Other models using gskch.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
h.mod
*
Other models using h.mod:
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
hha_old.mod
*
Other models using hha_old.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
hha2.mod
*
Other models using hha2.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
hNa.mod
*
Other models using hNa.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
IA.mod
*
Other models using IA.mod:
Active dendrites and spike propagation in a hippocampal interneuron (Saraga et al 2003)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
ichan2.mod
*
Other models using ichan2.mod:
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Ih.mod
*
Other models using Ih.mod:
Active dendrites and spike propagation in a hippocampal interneuron (Saraga et al 2003)
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
kad.mod
*
Other models using kad.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
kap.mod
*
Other models using kap.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Kaxon.mod
*
Other models using Kaxon.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
kca.mod
*
Other models using kca.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
Kdend.mod
*
Other models using Kdend.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
km.mod
*
Other models using km.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009)
Ksoma.mod
*
Other models using Ksoma.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
LcaMig.mod
*
Other models using LcaMig.mod:
Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
my_exp2syn.mod
*
Other models using my_exp2syn.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Naaxon.mod
*
Other models using Naaxon.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Nadend.mod
*
Other models using Nadend.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Nasoma.mod
*
Other models using Nasoma.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
nca.mod
*
Other models using nca.mod:
Basket cell extrasynaptic inhibition modulates network oscillations (Proddutur et al., 2013)
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
nmda.mod
*
Other models using nmda.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
regn_stim.mod
*
Other models using regn_stim.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
somacar.mod
*
Other models using somacar.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
STDPE2Syn.mod
*
Other models using STDPE2Syn.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
axoaxonic_cell17S.hoc
*
Other models using axoaxonic_cell17S.hoc:
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
basket_cell17S.hoc
*
Other models using basket_cell17S.hoc:
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
bistratified_cell13S.hoc
*
Other models using bistratified_cell13S.hoc:
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
burst_cell.hoc
*
Other models using burst_cell.hoc:
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
HAM_SR.ses
HAM_StoRec_par.hoc
HAM_StoRec_ser.hoc
mosinit.hoc
olm_cell2.hoc
pyramidal_cell_14Vb.hoc
ranstream.hoc
*
Other models using ranstream.hoc:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
Translating network models to parallel hardware in NEURON (Hines and Carnevale 2008)
stim_cell.hoc
*
Other models using stim_cell.hoc:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
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