Simulation studies on mechanisms of levetiracetam-mediated inhibition of IK(DR) (Huang et al. 2009)

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Accession:125154
Levetiracetam (LEV) is an S-enantiomer pyrrolidone derivative with established antiepileptic efficacy in generalized epilepsy and partial epilepsy. However, its effects on ion currents and membrane potential remain largely unclear. In this study, we investigated the effect of LEV on differentiated NG108-15 neurons. ... Simulation studies in a modified Hodgkin-Huxley neuron and network unraveled that the reduction of slowly inactivating IK(DR) resulted in membrane depolarization accompanied by termination of the firing of action potentials in a stochastic manner. Therefore, the inhibitory effects on slowly inactivating IK(DR) (Kv3.1-encoded current) may constitute one of the underlying mechanisms through which LEV affects neuronal activity in vivo.
Reference:
1 . Huang CW, Tsai JJ, Huang CC, Wu SN (2009) Experimental and simulation studies on the mechanisms of levetiracetam-mediated inhibition of delayed-rectifier potassium current (KV3.1): contribution to the firing of action potentials. J Physiol Pharmacol 60:37-47 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Connectionist Network;
Brain Region(s)/Organism:
Cell Type(s): Neuroblastoma; NG108-15 neuronal cell;
Channel(s): I Sodium; I Potassium; I_KHT;
Gap Junctions:
Receptor(s):
Gene(s): Kv3.1 KCNC1;
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Activity Patterns; Action Potentials;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Huang, Chin-Wei;
Search NeuronDB for information about:  I Sodium; I Potassium; I_KHT;
 
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