"... we measured T-type current of isolated
goldfish retinal ganglion cells with perforated-patch voltageclamp
methods in solutions containing a normal extracellular Ca2+
The voltage sensitivities and rates of current activation,
inactivation, deactivation, and recovery from inactivation were similar
to those of expressed +1G (CaV3.1) Ca2+ channel clones, except that
the rate of deactivation was significantly faster.
We reproduced the
amplitude and kinetics of measured T currents with a numerical
simulation based on a kinetic model developed for an +1G Ca2+
Finally, we show that this model predicts the increase of
T-type current made available between resting potential and spike
threshold by repetitive hyperpolarizations presented at rates that are
within the bandwidth of signals processed in situ by these neurons."
Lee SC, Hayashida Y, Ishida AT (2003) Availability of low-threshold Ca2+ current in retinal ganglion cells. J Neurophysiol 90:3888-901 [PubMed]