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Computer model of clonazepam's effect in thalamic slice (Lytton 1997)
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Accession:
12631
Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Reference:
1 .
Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice.
Neuroreport
8
:3339-43
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Thalamus;
Cell Type(s):
Thalamus geniculate nucleus/lateral principal GLU cell;
Thalamus reticular nucleus GABA cell;
Channel(s):
I Na,t;
I T low threshold;
I K;
I CAN;
Gap Junctions:
Receptor(s):
GabaA;
Gaba;
Gene(s):
Transmitter(s):
Gaba;
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Bursting;
Therapeutics;
Epilepsy;
Calcium dynamics;
Implementer(s):
Lytton, William [bill.lytton at downstate.edu];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
Thalamus reticular nucleus GABA cell
;
GabaA
;
Gaba
;
I Na,t
;
I T low threshold
;
I K
;
I CAN
;
Gaba
;
Download the displayed file
/
lytton97b
README
AMPA.mod
calciumpump_destexhe.mod
*
Other models using calciumpump_destexhe.mod:
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
GABAA.mod
GABAB1.mod
GABALOW.mod
HH_traub.mod
*
Other models using HH_traub.mod:
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
IAHP_destexhe.mod
ICAN_destexhe.mod
ICAN_voltdep.mod
Ih_old.mod
*
Other models using Ih_old.mod:
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
IT_wang.mod
IT2_huguenard.mod
NMDA.mod
passiv.mod
*
Other models using passiv.mod:
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Hippocampus temporo-septal engram shift model (Lytton 1999)
pregen.mod
*
Other models using pregen.mod:
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
presyn.mod
*
Other models using presyn.mod:
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
pulse.mod
rand.mod
bg.inc
*
Other models using bg.inc:
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Hippocampus temporo-septal engram shift model (Lytton 1999)
boxes.hoc
ctl.dat
ctlnew.dat
czp.dat
czpnew.dat
declist.hoc
*
Other models using declist.hoc:
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Hippocampus temporo-septal engram shift model (Lytton 1999)
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
decvec.hoc
*
Other models using decvec.hoc:
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Hippocampus temporo-septal engram shift model (Lytton 1999)
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
default.hoc
*
Other models using default.hoc:
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Hippocampus temporo-septal engram shift model (Lytton 1999)
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
disp.hoc
Fig3.gif
Fig4.gif
geom.hoc
grvec.hoc
init.hoc
labels.hoc
local.hoc
mod_func.c
mosinit.hoc
network.hoc
neurrep8
nrnoc.hoc
params.hoc
presyn.inc
*
Other models using presyn.inc:
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
queue.inc
*
Other models using queue.inc:
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
run.hoc
show.hoc
simctrl.hoc
*
Other models using simctrl.hoc:
Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Computational Surgery (Lytton et al. 2011)
Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)
Electrostimulation to reduce synaptic scaling driven progression of Alzheimers (Rowan et al. 2014)
Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Hippocampus temporo-septal engram shift model (Lytton 1999)
Hopfield and Brody model (Hopfield, Brody 2000) (NEURON+python)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Motor cortex microcircuit simulation based on brain activity mapping (Chadderdon et al. 2014)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
Prosthetic electrostimulation for information flow repair in a neocortical simulation (Kerr 2012)
Reinforcement learning of targeted movement (Chadderdon et al. 2012)
Sensorimotor cortex reinforcement learning of 2-joint virtual arm reaching (Neymotin et al. 2013)
Synaptic scaling balances learning in a spiking model of neocortex (Rowan & Neymotin 2013)
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
sns.inc
*
Other models using sns.inc:
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
snsarr.inc
snscode.hoc
snsgr.hoc
snshead.inc
*
Other models using snshead.inc:
Feedforward heteroassociative network with HH dynamics (Lytton 1998)
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
synq.inc
*
Other models using synq.inc:
Thalamic quiescence of spike and wave seizures (Lytton et al 1997)
xtmp
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