"... Based on realistic modeling and experiments in rat hippocampal
slices, we derived a simple arithmetic rule for spatial summation
of concurrent excitatory glutamatergic inputs (E) and inhibitory
GABAergic inputs (I).
The somatic response can be well approximated
as the sum of the excitatory postsynaptic potential (EPSP), the inhibitory
postsynaptic potential (IPSP), and a nonlinear term proportional
to their product (k*EPSP*IPSP), where the coefficient k reflects the
strength of shunting effect.
..."
Reference:
1 .
Hao J, Wang XD, Dan Y, Poo MM, Zhang XH (2009) An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons. Proc Natl Acad Sci U S A 106:21906-11 [PubMed]
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