"... In a two-stage integration model, inputs contribute directly to dendritic spikes, and outputs from multiple branches sum in the axon. ... We used serial-section electron microscopy to reconstruct individual apical oblique dendritic branches of CA1 pyramidal neurons and observe a synapse distribution consistent with the two-stage integration model. Computational modeling suggests that the observed synapse distribution enhances the contribution of each dendritic branch to neuronal output."
Katz Y, Menon V, Nicholson DA, Geinisman Y, Kath WL, Spruston N (2009) Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons. Neuron 63:171-7 [PubMed]