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Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)
 
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Accession:
127507
A dopaminergic (DA) neuron model with a morphologicaly realistic dendritic architecture. The model captures several salient features of DA neurons under different pharmacological manipulations and exhibits depolarization block for sufficiently high current pulses applied to the soma.
Reference:
1 .
Kuznetsova AY, Huertas MA, Kuznetsov AS, Paladini CA, Canavier CC (2010) Regulation of firing frequency in a computational model of a midbrain dopaminergic neuron.
J Comput Neurosci
28
:389-403
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Basal ganglia;
Cell Type(s):
Substantia nigra pars compacta DA cell;
Channel(s):
I Na,t;
I L high threshold;
I N;
I T low threshold;
I A;
I K;
I K,Ca;
Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Temporal Pattern Generation;
Oscillations;
Implementer(s):
Huertas, Marco [huertas.marco at gmail.com];
Search NeuronDB
for information about:
Substantia nigra pars compacta DA cell
;
I Na,t
;
I L high threshold
;
I N
;
I T low threshold
;
I A
;
I K
;
I K,Ca
;
Na/K pump
;
/
KuznetsovaEtAl2010
README.html
cabal.mod
*
Other models using cabal.mod:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
Role of the AIS in the control of spontaneous frequency of dopaminergic neurons (Meza et al 2017)
VTA neurons: Morphofunctional alterations in acute opiates withdrawal (Enrico et al. 2016)
nabalan.mod
*
Other models using nabalan.mod:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
Role of the AIS in the control of spontaneous frequency of dopaminergic neurons (Meza et al 2017)
newcachan.mod
*
Other models using newcachan.mod:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
Role of the AIS in the control of spontaneous frequency of dopaminergic neurons (Meza et al 2017)
newhh3.mod
newkca.mod
newleak.mod
pump.mod
*
Other models using pump.mod:
VTA neurons: Morphofunctional alterations in acute opiates withdrawal (Enrico et al. 2016)
stim.mod
dopaminergic.hoc
Fig2a2.hoc
Fig2b2.hoc
Fig2f2.hoc
Fig6a_dashed-line_trace.hoc
Fig6a_solid_trace.hoc
final.hoc
fixnseg.hoc
*
Other models using fixnseg.hoc:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
Role of the AIS in the control of spontaneous frequency of dopaminergic neurons (Meza et al 2017)
mosinit.hoc
run_and_graph.ses
screenshot2a2.jpg
screenshot2b2.jpg
screenshot2f2.jpg
screenshot6a_d.jpg
screenshot6a_s.jpg
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