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Comparison of full and reduced globus pallidus models (Hendrickson 2010)

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Accession:127728
In this paper, we studied what features of realistic full model activity patterns can and cannot be preserved by morphologically reduced models. To this end, we reduced the morphological complexity of a full globus pallidus neuron model possessing active dendrites and compared its spontaneous and driven responses to those of the reduced models.
Reference:
1 . Hendrickson EB, Edgerton JR, Jaeger D (2011) The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites. J Comput Neurosci 30:301-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Globus pallidus neuron;
Channel(s): I Na,p; I A; I K; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Simplified Models; Active Dendrites; Action Potentials; Methods; Rate-coding model neurons; Synaptic Integration;
Implementer(s): Hendrickson, Eric B [eric.b.hendrickson at gmail.com];
Search NeuronDB for information about:  AMPA; NMDA; Gaba; I Na,p; I A; I K; I K,Ca; I Calcium; I A, slow; Gaba; Glutamate;
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articleCode
commonGPRedu
.actpars.g.swp
.GPchans.g.swp
.nautilus-metafile.xml
actpars.g
GP1_14comp.p
GP1_1comp.p
GP1_41comp.p
GP1_50comp.p
GP1_59comp.p
GP1_5comp.p
GP1_93comp.p
GP1_98comp.p
gp1allcompnames_14comp.asc
gp1allcompnames_41comp.asc
gp1allcompnames_50comp.asc
gp1allcompnames_59comp.asc
gp1allcompnames_5comp.asc
gp1allcompnames_93comp.asc
gp1allcompnames_98comp.asc
GP1axonless_defaults_full.g
gp1dendritenames_14comp.asc
gp1dendritenames_14comp_forSyns.asc
gp1dendritenames_41comp.asc
gp1dendritenames_41comp_forSyns.asc
gp1dendritenames_50comp.asc
gp1dendritenames_50comp_forSyns.asc
gp1dendritenames_59comp.asc
gp1dendritenames_59comp_forSyns.asc
gp1dendritenames_5comp.asc
gp1dendritenames_5comp_forSyns.asc
gp1dendritenames_93comp.asc
gp1dendritenames_93comp_forSyns.asc
gp1dendritenames_93comp_sortedByEdist.asc
gp1dendritenames_98comp.asc
gp1dendritenames_98comp_forSyns.asc
gp1dendritenames_98comp_sortedByEdist.asc
gp1singleEPSPcompname_93comp.asc
gp1singleEPSPcompname_98comp.asc
GPchans.g *
GPcomps.g
GPcomps_nochans.g
GPsyns.g *
make_GP_library.g
make_GP_library_nochans.g
midDistACompts_93comp.asc
randseeds.asc *
read_mvDir_basefilename.g
reduced_read_STN_syns_clusteredSynch.g
reduced_read_STN_syns_inclNMDA.g
reduced_read_STN_syns_inclNMDA_atCertainTimes.g
reduced_read_striatum_syns.g
simdefaults.g
simulateSynaptic_14comp_clusteredSynch.g
simulateSynaptic_14comp_inclNMDA.g
simulateSynaptic_41comp_clusteredSynch.g
simulateSynaptic_41comp_inclNMDA.g
simulateSynaptic_50comp_clusteredSynch.g
simulateSynaptic_50comp_inclNMDA.g
simulateSynaptic_59comp_clusteredSynch.g
simulateSynaptic_59comp_inclNMDA.g
simulateSynaptic_5comp_clusteredSynch.g
simulateSynaptic_5comp_inclNMDA.g
simulateSynaptic_5comp_individualClusters.g
simulateSynaptic_93comp_clusteredSynch.g
simulateSynaptic_93comp_inclNMDA.g
simulateSynaptic_93comp_singleEPSP.g
simulateSynaptic_98comp_clusteredSynch.g
simulateSynaptic_98comp_inclNMDA.g
simulateSynaptic_98comp_singleEPSP.g
                            
// GENESIS script: GP model synaptic properties
// Created by Jesse Hanson
// Modified:
//	08/2004: channel time constants made variables.

float IncF = 1.4
float IncD = .9
float tauF = .241
float tauD = .491
function make_GP_syns
	if (!({exists AMPA}))
		create synchan AMPA
	end
	setfield AMPA Ek {E_AMPA} tau1 {tauRise_AMPA} tau2 {tauFall_AMPA} \
		gmax {G_AMPA} frequency 0 

/*	if (!({exists stpAMPA}))
                create stpsynchan stpAMPA
        end
        setfield stpAMPA Ek {E_AMPA} tau1 1e-3 tau2 3e-3 gmax {G_AMPA} \
		fac_per_spike {IncF} depr_per_spike {IncD}   \
                fac_tau {tauF}  depr_tau {tauD}              \
                max_fac 5
*/	
	if (!({exists NMDA}))
                create synchan NMDA
        end
	setfield NMDA Ek {E_NMDA} tau1 {tauRise_NMDA} tau2 {tauFall_NMDA} \
		gmax {G_NMDA} frequency 0
	
	if (!({exists Mg_block}))
                create Mg_block Mg_block 
        end
	setfield Mg_block		\
		CMg    0.25		\
		KMg_A  1		\
		KMg_B  {1/{0.057*1000}}

	if (!({exists GABA}))
	       	create synchan GABA
	end
	setfield GABA Ek {E_GABA} tau1 {tauRise_GABA} tau2 {tauFall_GABA}  \
		gmax {G_GABA} frequency 0

	if (!({exists GABA_GP}))
	       	create synchan GABA_GP
	end
	setfield GABA_GP Ek {E_GABA} tau1 {tauRise_GABA_GP} \
		tau2 {tauFall_GABA_GP} gmax {G_GABA_GP} frequency 0
end


function make_GP_AMPA
	if (!({exists AMPA}))
		create synchan AMPA
	end
	setfield AMPA Ek {E_AMPA} tau1 {tauRise_AMPA} tau2 {tauFall_AMPA} \
		gmax {G_AMPA} frequency 0 
end

function make_GP_GABA_striatum
	if (!({exists GABA}))
	       	create synchan GABA
	end
	setfield GABA Ek {E_GABA} tau1 {tauRise_GABA} tau2 {tauFall_GABA}  \
		gmax {G_GABA} frequency 0
end

function make_GP_GABA_pallidum
	if (!({exists GABA_GP}))
	       	create synchan GABA_GP
	end
	setfield GABA_GP Ek {E_GABA} tau1 {tauRise_GABA_GP} \
		tau2 {tauFall_GABA_GP} gmax {G_GABA_GP} frequency 0
end



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