"The electrical characteristics of many neurons are remarkably
robust in the face of changing internal and external conditions.
At the same time, neurons can be highly sensitive to neuromodulators.
We find correlates of this dual robustness and
sensitivity in a global analysis of the structure of a
conductance-based model neuron.
Goldman MS, Golowasch J, Marder E, Abbott LF (2001) Global structure, robustness, and modulation of neuronal models. J Neurosci 21:5229-38 [PubMed]