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Selective control of cortical axonal spikes by a slowly inactivating K+ current (Shu et al. 2007)
 
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Accession:
135898
We discovered a low-threshold, slowly inactivating K+ current, containing Kv1.2 alpha subunits, in axon initial segment, playing a key role in the modulation of spike threshold and spike duration as well as the spike timing in prefrontal cortex layer V pyramidal cell of ferrets and rats. A kd.mod file implements this D current and put it in the axonal model: Neuron_Dcurrent.hoc. Run the model to see the gradual modulation effect over seconds on spike shape.
Reference:
1 .
Shu Y, Yu Y, Yang J, McCormick DA (2007) Selective control of cortical axonal spikes by a slowly inactivating K+ current.
Proc Natl Acad Sci U S A
104
:11453-8
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Axon;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Channel(s):
I Na,t;
I K;
I h;
I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Kv1.2 KCNA2;
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Action Potentials;
Implementer(s):
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
I Na,t
;
I K
;
I h
;
I Potassium
;
/
YuEtAlPNAS2007
readme.txt
Gfluct.mod
*
Other models using Gfluct.mod:
AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)
Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)
h.mod
*
Other models using h.mod:
Ih levels roles in bursting and regular-spiking subiculum pyramidal neurons (van Welie et al 2006)
kd.mod
*
Other models using kd.mod:
Spike repolarization in axon collaterals (Foust et al. 2011)
kv.mod
*
Other models using kv.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Mechanisms of magnetic stimulation of central nervous system neurons (Pashut et al. 2011)
Pyramidal neuron coincidence detection tuned by dendritic branching pattern (Schaefer et al 2003)
STDP depends on dendritic synapse location (Letzkus et al. 2006)
na.mod
*
Other models using na.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
Mechanisms of magnetic stimulation of central nervous system neurons (Pashut et al. 2011)
Pyramidal neuron coincidence detection tuned by dendritic branching pattern (Schaefer et al 2003)
STDP depends on dendritic synapse location (Letzkus et al. 2006)
Dcurrent_model.doc
mosinit.hoc
Neuron_Dcurrent.hoc
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