Striatal GABAergic microcircuit, spatial scales of dynamics (Humphries et al, 2010)

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Accession:137502
The main thrust of this paper was the development of the 3D anatomical network of the striatum's GABAergic microcircuit. We grew dendrite and axon models for the MSNs and FSIs and extracted probabilities for the presence of these neurites as a function of distance from the soma. From these, we found the probabilities of intersection between the neurites of two neurons given their inter-somatic distance, and used these to construct three-dimensional striatal networks. These networks were examined for their predictions for the distributions of the numbers and distances of connections for all the connections in the microcircuit. We then combined the neuron models from a previous model (Humphries et al, 2009; ModelDB ID: 128874) with the new anatomical model. We used this new complete striatal model to examine the impact of the anatomical network on the firing properties of the MSN and FSI populations, and to study the influence of all the inputs to one MSN within the network.
Reference:
1 . Humphries MD, Wood R, Gurney K (2010) Reconstructing the three-dimensional GABAergic microcircuit of the striatum. PLoS Comput Biol 6:e1001011 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum fast spiking interneuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Dopamine; Gaba; Glutamate;
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Spatio-temporal Activity Patterns; Winner-take-all; Connectivity matrix;
Implementer(s): Humphries, Mark D [m.d.humphries at shef.ac.uk]; Wood, Ric [ric.wood at shef.ac.uk];
Search NeuronDB for information about:  D1; D2; GabaA; AMPA; NMDA; Dopamine; Gaba; Glutamate;
function checkStriatumInputs(SIMPARAMS)

if ~isfloat(SIMPARAMS.sim.tstart); error('tstart is not a float'); end
if ~isfloat(SIMPARAMS.sim.tfinal); error('tfinal is not a float'); end
if ~isfloat(SIMPARAMS.sim.dt); error('dt is not a float'); end
if ~isfloat(SIMPARAMS.physiology.MSparams); error('MSparams is not a float'); end
if ~isfloat(SIMPARAMS.physiology.FSparams); error('FSparams is not a float'); end
if ~isfloat(SIMPARAMS.physiology.Eglu); error('Eglu is not a float'); end
if ~isfloat(SIMPARAMS.physiology.Egaba); error('Egaba is not a float'); end
if ~isfloat(SIMPARAMS.physiology.ts_glu_AMPA); error('ts_glu_AMPA is not a float'); end
if ~isfloat(SIMPARAMS.physiology.ts_glu_NMDA); error('ts_glu_NMDA is not a float'); end
if ~isfloat(SIMPARAMS.physiology.ts_gaba); error('ts_gaba is not a float'); end
if ~isfloat(SIMPARAMS.physiology.tau_fsgap); error('tau_fsgap is not a float'); end
if ~isinteger(SIMPARAMS.sim.MSspikebuffer); error('MSspikebuffer is not a integer'); end
if ~isinteger(SIMPARAMS.sim.FSspikebuffer); error('FSspikebuffer is not a integer'); end
if ~isfloat(SIMPARAMS.sim.initVms); error('initVms is not a float'); end
if ~isfloat(SIMPARAMS.sim.initUms); error('initUms is not a float'); end
if ~isfloat(SIMPARAMS.sim.initVfs); error('initVfs is not a float'); end
if ~isfloat(SIMPARAMS.sim.initUfs); error('initUfs is not a float'); end
if ~isfloat(SIMPARAMS.sim.initVgapfs); error('initVgapfs is not a float'); end
if ~isfloat(SIMPARAMS.sim.SpikeEventQue_MS); error('SpikeEventQue_MS is not a float'); end
if ~isfloat(SIMPARAMS.sim.SpikeEventQue_FS); error('SpikeEventQue_FS is not a float'); end
if ~isfloat(SIMPARAMS.initCTX); error('initCTX is not a float'); end
if ~isfloat(SIMPARAMS.sim.Iinj_MS); error('Iinj is not a float'); end
if ~isfloat(SIMPARAMS.sim.Iinj_FS); error('Iinj is not a float'); end
if ~isinteger(SIMPARAMS.net.Cctms); error('Cctms is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cctms_b); error('Cctms_b is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cctms_d); error('Cctms_d is not a integer'); end
if ~isfloat(SIMPARAMS.net.Cctms_w); error('Cctms_w is not a float'); end
if ~isinteger(SIMPARAMS.net.Cmsms); error('Cmsms is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cmsms_b); error('Cmsms_b is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cmsms_d); error('Cmsms_d is not a integer'); end
if ~isfloat(SIMPARAMS.net.Cmsms_w); error('Cmsms_w is not a float'); end
if ~isinteger(SIMPARAMS.net.Cfsms); error('Cfsms is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cfsms_b); error('Cfsms_b is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cfsms_d); error('Cfsms_d is not a integer'); end
if ~isfloat(SIMPARAMS.net.Cfsms_w); error('Cfsms_w is not a float'); end
if ~isinteger(SIMPARAMS.net.Cctfs); error('Cctfs is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cctfs_b); error('Cctfs_b is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cctfs_d); error('Cctfs_d is not a integer'); end
if ~isfloat(SIMPARAMS.net.Cctfs_w); error('Cctfs_w is not a float'); end
if ~isinteger(SIMPARAMS.net.Cfsfs); error('Cfsfs is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cfsfs_b); error('Cfsfs_b is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cfsfs_d); error('Cfsfs_d is not a integer'); end
if ~isfloat(SIMPARAMS.net.Cfsfs_w); error('Cfsfs_w is not a float'); end
if ~isinteger(SIMPARAMS.net.Cgapfs); error('Cgapfs is not a integer'); end
if ~isinteger(SIMPARAMS.net.Cgapfs_b); error('Cgapfs_b is not a integer'); end
if ~isfloat(SIMPARAMS.net.Cgapfs_w); error('Cgapfs_w is not a float'); end
if ~isinteger(SIMPARAMS.net.Pgapfs); error('Pgapfs is not a integer'); end
if ~isfloat(SIMPARAMS.CTX_state); error('CTX_state is not a float'); end
if ~isinteger(SIMPARAMS.net.CHAN1_MS); error('CHAN1_MS is not a integer'); end
if ~isinteger(SIMPARAMS.net.CHAN1_FS); error('CHAN1_FS is not a integer'); end
if ~isinteger(SIMPARAMS.net.CHAN2_MS); error('CHAN2_MS is not a integer'); end
if ~isinteger(SIMPARAMS.net.CHAN2_FS); error('CHAN2_FS is not a integer'); end
if ~isinteger(SIMPARAMS.input.CTX.N_MSSEG); error('N_MSSEG is not a integer'); end
if ~isfloat(SIMPARAMS.input.CTX.r_MSSEG); error('r_MSSEG is not a float'); end
if ~isfloat(SIMPARAMS.input.CTX.alpha_MSSEG); error('alpha_MSSEG is not a float'); end
if ~isinteger(SIMPARAMS.input.CTX.N_FSSEG); error('N_FSSEG is not a integer'); end
if ~isfloat(SIMPARAMS.input.CTX.r_FSSEG); error('r_FSSEG is not a float'); end
if ~isfloat(SIMPARAMS.input.CTX.alpha_FSSEG); error('alpha_FSSEG is not a float'); end
if ~isfloat(SIMPARAMS.physiology.glu_ratio); error('glu_ratio is not a float'); end
if ~isfloat(SIMPARAMS.physiology.DA); error('DA is not a float'); end
if ~isinteger(SIMPARAMS.sim.RecordChan_MS); error('RecordChan_MS is not a integer'); end
if ~isfloat(SIMPARAMS.input.PULSE.P); error('PULSE.P is not a float'); end
if ~isfloat(SIMPARAMS.input.PULSE.Nctx_ms); error('PULSE.Nctx_ms is not a float'); end
if ~isfloat(SIMPARAMS.input.PULSE.Nctx_fs); error('PULSE.Nctx_fs is not a float'); end
if ~isfloat(SIMPARAMS.input.PULSE.ts_spks); error('PULSE.ts_spks is not a float'); end
if ~isinteger(SIMPARAMS.sim.RANDSEED); error('RANDSEED is not a integer'); end



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