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GP Neuron, somatic and dendritic phase response curves (Schultheiss et al. 2011)

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Accession:137846
Phase response analysis of a GP neuron model showing type I PRCs for somatic inputs and type II PRCs for dendritic excitation. Analysis of intrinsic currents underlying type II dendritic PRCs.
Reference:
1 . Schultheiss NW, Edgerton JR, Jaeger D (2010) Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration. J Neurosci 30:2767-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations; Synchronization; Active Dendrites; Synaptic Integration; Parkinson's; Phase Response Curves;
Implementer(s): Edgerton, Jeremy R. [jedgert at emory.edu]; Hanson, Jesse E.; Schultheiss, Nathan W [nwschultheiss at gmail.com];
// Modified 08/04/2004: if statements for pallidum_rate == 0 condition added.

/*script to add synapses to GP model*/

randseed {rseed_GP} 
int i
float d,l,surf
str pallidumcompartment

//create input element tree outside of the cell path
if (!{exists /inputs})
	create neutral /inputs
end
create neutral /inputs/pallidum
create neutral /inputs/pallidum/soma

copy /library/GABA_GP {cellpath}/soma/GABA_GP
addmsg  {cellpath}/soma/GABA_GP {cellpath}/soma CHANNEL Gk Ek
addmsg  {cellpath}/soma {cellpath}/soma/GABA_GP VOLTAGE Vm

for (i = 1; i <= {num_pallidal}; i = i + 1)
	create timetable /inputs/pallidum/soma/timetable[{i}]
	if ({pallidum_rate} > 0)
           setfield /inputs/pallidum/soma/timetable[{i}]		\
           	maxtime 200 act_val 1.0 method 2                 	\
        	meth_desc1 {1/{pallidum_rate}} meth_desc2 0.005 meth_desc3 3
        	call /inputs/pallidum/soma/timetable[{i}] TABFILL 
	end
	
	//set up spikegen
        create spikegen /inputs/pallidum/soma/spikegen[{i}]
        setfield /inputs/pallidum/soma/spikegen[{i}]			\
                output_amp 1 thresh 0.5
		
        //connect timetables to GABA synapses
	if (({pallidum_rate} > 0) && ({isa leakage {cellpath}/soma/GABA_GP} != 1))
        	addmsg /inputs/pallidum/soma/timetable[{i}] 		\
			/inputs/pallidum/soma/spikegen[{i}] INPUT activation
        	addmsg /inputs/pallidum/soma/spikegen[{i}] 		\
                	{cellpath}/soma/GABA_GP SPIKE
	end
end



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