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GP Neuron, somatic and dendritic phase response curves (Schultheiss et al. 2011)

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Accession:137846
Phase response analysis of a GP neuron model showing type I PRCs for somatic inputs and type II PRCs for dendritic excitation. Analysis of intrinsic currents underlying type II dendritic PRCs.
Reference:
1 . Schultheiss NW, Edgerton JR, Jaeger D (2010) Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration. J Neurosci 30:2767-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations; Synchronization; Active Dendrites; Synaptic Integration; Parkinson's; Phase Response Curves;
Implementer(s): Edgerton, Jeremy R. [jedgert at emory.edu]; Hanson, Jesse E.; Schultheiss, Nathan W [nwschultheiss at gmail.com];
//actpars - set conductance densities for the non-spiking dendrite model
//	Any param value can be overwritten subsequently.
// THIS VERSION CURRENT 08/09/2005 to present.

str snapshotname = {snapshot_pas}

//Voltage-gated ion channel densities
float G_Na_fast_GP  	= 350 	 
float G_Na_slow_GP  	= 1.015
float G_Kv3_GP  	= 11.25
float G_Kv2_GP  	= 1 	
float G_Kv4_fast_GP 	= 20 
float G_Kv4_slow_GP = {G_Kv4_fast_GP}*1.5
float G_KCNQ_GP 	= 2
float G_Ca_HVA_GP   	= 0.3	
float G_K_ahp_GP    	= 4
float G_h_HCN_GP    	= 0.2
float G_h_HCN2_GP   	= {G_h_HCN_GP}*2.5

//Multipliers for conductance densities
float G_mult 			= 1
float G_mult_Na_dend   	= 0
float G_mult_Kdr_dend  	= 0
float G_mult_KA_dend   	= 2
float G_mult_KCNQ_dend	= 1
float G_mult_SK_dend	= 0.87
float G_mult_Ca_dend 	= 0.44
float G_mult_HCN_dend	= 1
float G_mult_Na_soma    = 23 
float G_mult_Kdr_soma   = 23
float G_mult_KA_soma    = 2
float G_mult_KCNQ_soma	= 5.2
float G_mult_SK_soma	= 39.6
float G_mult_Ca_soma	= 1.29
float G_mult_Na_axon 	= 57
float G_mult_Kdr_axon 	= 40
float G_mult_KA_axon 	= 40
float G_mult_KCNQ_axon	= 40


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