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GP Neuron, somatic and dendritic phase response curves (Schultheiss et al. 2011)

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Accession:137846
Phase response analysis of a GP neuron model showing type I PRCs for somatic inputs and type II PRCs for dendritic excitation. Analysis of intrinsic currents underlying type II dendritic PRCs.
Reference:
1 . Schultheiss NW, Edgerton JR, Jaeger D (2010) Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration. J Neurosci 30:2767-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations; Synchronization; Active Dendrites; Synaptic Integration; Parkinson's; Phase Response Curves;
Implementer(s): Edgerton, Jeremy R. [jedgert at emory.edu]; Hanson, Jesse E.; Schultheiss, Nathan W [nwschultheiss at gmail.com]; 
// for confirming distribution of spike currents from soma to dendrite:
str mycompt
float NaF_soma_Gtot = 0
float NaS_soma_Gtot = 0
float KV2_soma_Gtot = 0
float KV3_soma_Gtot = 0
float NaF_dend_Gtot = 0
float NaS_dend_Gtot = 0
float KV2_dend_Gtot = 0
float KV3_dend_Gtot = 0

float Na_fast_GP_tmpVal
float Na_fast_GP_somahill_tmpVal
float Na_fast_GP_dend3_distal25compts_tmpVal
float Na_fast_GP_dend3_mid25compts_tmpVal
float Na_fast_GP_dend3_proximal25compts_tmpVal
float Na_fast_GP_dend2_distal25compts_tmpVal
float Na_fast_GP_dend2_proximal25compts_tmpVal
float Na_fast_GP_dend1_distal25compts_tmpVal
float Na_fast_GP_dend1_proximal25compts_tmpVal

float Na_slow_GP_tmpVal
float Na_slow_GP_somahill_tmpVal
float Na_slow_GP_dend3_distal25compts_tmpVal
float Na_slow_GP_dend3_mid25compts_tmpVal
float Na_slow_GP_dend3_proximal25compts_tmpVal
float Na_slow_GP_dend2_distal25compts_tmpVal
float Na_slow_GP_dend2_proximal25compts_tmpVal
float Na_slow_GP_dend1_distal25compts_tmpVal
float Na_slow_GP_dend1_proximal25compts_tmpVal

float Kv2_GP_tmpVal
float Kv2_GP_somahill_tmpVal
float Kv2_GP_dend3_distal25compts_tmpVal
float Kv2_GP_dend3_mid25compts_tmpVal
float Kv2_GP_dend3_proximal25compts_tmpVal
float Kv2_GP_dend2_distal25compts_tmpVal
float Kv2_GP_dend2_proximal25compts_tmpVal
float Kv2_GP_dend1_distal25compts_tmpVal
float Kv2_GP_dend1_proximal25compts_tmpVal

float Kv3_GP_tmpVal
float Kv3_GP_somahill_tmpVal
float Kv3_GP_dend3_distal25compts_tmpVal
float Kv3_GP_dend3_mid25compts_tmpVal
float Kv3_GP_dend3_proximal25compts_tmpVal
float Kv3_GP_dend2_distal25compts_tmpVal
float Kv3_GP_dend2_proximal25compts_tmpVal
float Kv3_GP_dend1_distal25compts_tmpVal
float Kv3_GP_dend1_proximal25compts_tmpVal


float echoGate = 0

foreach mycompt ({el {cellpath}/##[][OBJECT=compartment]})

// NaFast

    if ({exists {mycompt}/Na_fast_GP})
        Na_fast_GP_tmpVal = {({getfield {mycompt}/Na_fast_GP Gbar})}
        NaF_dend_Gtot = {NaF_dend_Gtot} + {Na_fast_GP_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaF {({getfield {mycompt}/Na_fast_GP Gbar})}
        end
    end

    if ({exists {mycompt}/Na_fast_GP_somahill})
        Na_fast_GP_somahill_tmpVal = {({getfield {mycompt}/Na_fast_GP_somahill Gbar})}
        NaF_soma_Gtot = {NaF_soma_Gtot} + {Na_fast_GP_somahill_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaF {({getfield {mycompt}/Na_fast_GP_somahill Gbar})}
        end
    end

    if ({exists {mycompt}/Na_fast_GP_dend3_distal25compts})
        Na_fast_GP_dend3_distal25compts_tmpVal = {({getfield {mycompt}/Na_fast_GP_dend3_distal25compts Gbar})}
        NaF_dend_Gtot = {NaF_dend_Gtot} + {Na_fast_GP_dend3_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaF {({getfield {mycompt}/Na_fast_GP_dend3_distal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_fast_GP_dend3_mid25compts})
        Na_fast_GP_dend3_mid25compts_tmpVal = {({getfield {mycompt}/Na_fast_GP_dend3_mid25compts Gbar})}
        NaF_dend_Gtot = {NaF_dend_Gtot} + {Na_fast_GP_dend3_mid25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaF {({getfield {mycompt}/Na_fast_GP_dend3_mid25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_fast_GP_dend3_proximal25compts})
        Na_fast_GP_dend3_proximal25compts_tmpVal = {({getfield {mycompt}/Na_fast_GP_dend3_proximal25compts Gbar})}
        NaF_dend_Gtot = {NaF_dend_Gtot} + {Na_fast_GP_dend3_proximal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaF {({getfield {mycompt}/Na_fast_GP_dend3_proximal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_fast_GP_dend2_distal25compts})
        Na_fast_GP_dend2_distal25compts_tmpVal = {({getfield {mycompt}/Na_fast_GP_dend2_distal25compts Gbar})}
        NaF_dend_Gtot = {NaF_dend_Gtot} + {Na_fast_GP_dend2_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaF {({getfield {mycompt}/Na_fast_GP_dend2_distal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_fast_GP_dend2_proximal25compts})
        Na_fast_GP_dend2_proximal25compts_tmpVal = {({getfield {mycompt}/Na_fast_GP_dend2_proximal25compts Gbar})}
        NaF_dend_Gtot = {NaF_dend_Gtot} + {Na_fast_GP_dend2_proximal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaF {({getfield {mycompt}/Na_fast_GP_dend2_proximal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_fast_GP_dend1_distal25compts})
        Na_fast_GP_dend1_distal25compts_tmpVal = {({getfield {mycompt}/Na_fast_GP_dend1_distal25compts Gbar})}
        NaF_dend_Gtot = {NaF_dend_Gtot} + {Na_fast_GP_dend1_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaF {({getfield {mycompt}/Na_fast_GP_dend1_distal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_fast_GP_dend1_proximal25compts})
        Na_fast_GP_dend1_proximal25compts_tmpVal = {({getfield {mycompt}/Na_fast_GP_dend1_proximal25compts Gbar})}
        NaF_dend_Gtot = {NaF_dend_Gtot} + {Na_fast_GP_dend1_proximal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaF {({getfield {mycompt}/Na_fast_GP_dend1_proximal25compts Gbar})}
        end
    end


// NaSlow

    if ({exists {mycompt}/Na_slow_GP})
        Na_slow_GP_tmpVal = {({getfield {mycompt}/Na_slow_GP Gbar})}
        NaS_dend_Gtot = {NaS_dend_Gtot} + {Na_slow_GP_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaS {({getfield {mycompt}/Na_slow_GP Gbar})}
        end
    end

    if ({exists {mycompt}/Na_slow_GP_somahill})
        Na_slow_GP_somahill_tmpVal = {({getfield {mycompt}/Na_slow_GP_somahill Gbar})}
        NaS_soma_Gtot = {NaS_soma_Gtot} + {Na_slow_GP_somahill_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaS {({getfield {mycompt}/Na_slow_GP_somahill Gbar})}
        end
    end

    if ({exists {mycompt}/Na_slow_GP_dend3_distal25compts})
        Na_slow_GP_dend3_distal25compts_tmpVal = {({getfield {mycompt}/Na_slow_GP_dend3_distal25compts Gbar})}
        NaS_dend_Gtot = {NaS_dend_Gtot} + {Na_slow_GP_dend3_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaS {({getfield {mycompt}/Na_slow_GP_dend3_distal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_slow_GP_dend3_mid25compts})
        Na_slow_GP_dend3_mid25compts_tmpVal = {({getfield {mycompt}/Na_slow_GP_dend3_mid25compts Gbar})}
        NaS_dend_Gtot = {NaS_dend_Gtot} + {Na_slow_GP_dend3_mid25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaS {({getfield {mycompt}/Na_slow_GP_dend3_mid25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_slow_GP_dend3_proximal25compts})
        Na_slow_GP_dend3_proximal25compts_tmpVal = {({getfield {mycompt}/Na_slow_GP_dend3_proximal25compts Gbar})}
        NaS_dend_Gtot = {NaS_dend_Gtot} + {Na_slow_GP_dend3_proximal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaS {({getfield {mycompt}/Na_slow_GP_dend3_proximal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_slow_GP_dend2_distal25compts})
        Na_slow_GP_dend2_distal25compts_tmpVal = {({getfield {mycompt}/Na_slow_GP_dend2_distal25compts Gbar})}
        NaS_dend_Gtot = {NaS_dend_Gtot} + {Na_slow_GP_dend2_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaS {({getfield {mycompt}/Na_slow_GP_dend2_distal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_slow_GP_dend2_proximal25compts})
        Na_slow_GP_dend2_proximal25compts_tmpVal = {({getfield {mycompt}/Na_slow_GP_dend2_proximal25compts Gbar})}
        NaS_dend_Gtot = {NaS_dend_Gtot} + {Na_slow_GP_dend2_proximal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaS {({getfield {mycompt}/Na_slow_GP_dend2_proximal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Na_slow_GP_dend1_distal25compts})
        Na_slow_GP_dend1_distal25compts_tmpVal = {({getfield {mycompt}/Na_slow_GP_dend1_distal25compts Gbar})}
        NaS_dend_Gtot = {NaS_dend_Gtot} + {Na_slow_GP_dend1_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} NaS {({getfield {mycompt}/Na_slow_GP_dend1_distal25compts Gbar})}
        end
    end


// KV2

    if ({exists {mycompt}/Kv2_GP})
        Kv2_GP_tmpVal = {({getfield {mycompt}/Kv2_GP Gbar})}
        KV2_dend_Gtot = {KV2_dend_Gtot} + {Kv2_GP_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV2 {({getfield {mycompt}/Kv2_GP Gbar})}
        end
    end

    if ({exists {mycompt}/Kv2_GP_somahill})
        Kv2_GP_somahill_tmpVal = {({getfield {mycompt}/Kv2_GP_somahill Gbar})}
        KV2_soma_Gtot = {KV2_soma_Gtot} + {Kv2_GP_somahill_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV2 {({getfield {mycompt}/Kv2_GP_somahill Gbar})}
        end
    end

    if ({exists {mycompt}/Kv2_GP_dend3_distal25compts})
        Kv2_GP_dend3_distal25compts_tmpVal = {({getfield {mycompt}/Kv2_GP_dend3_distal25compts Gbar})}
        KV2_dend_Gtot = {KV2_dend_Gtot} + {Kv2_GP_dend3_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV2 {({getfield {mycompt}/Kv2_GP_dend3_distal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv2_GP_dend3_mid25compts})
        Kv2_GP_dend3_mid25compts_tmpVal = {({getfield {mycompt}/Kv2_GP_dend3_mid25compts Gbar})}
        KV2_dend_Gtot = {KV2_dend_Gtot} + {Kv2_GP_dend3_mid25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV2 {({getfield {mycompt}/Kv2_GP_dend3_mid25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv2_GP_dend3_proximal25compts})
        Kv2_GP_dend3_proximal25compts_tmpVal = {({getfield {mycompt}/Kv2_GP_dend3_proximal25compts Gbar})}
        KV2_dend_Gtot = {KV2_dend_Gtot} + {Kv2_GP_dend3_proximal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV2 {({getfield {mycompt}/Kv2_GP_dend3_proximal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv2_GP_dend2_distal25compts})
        Kv2_GP_dend2_distal25compts_tmpVal = {({getfield {mycompt}/Kv2_GP_dend2_distal25compts Gbar})}
        KV2_dend_Gtot = {KV2_dend_Gtot} + {Kv2_GP_dend2_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV2 {({getfield {mycompt}/Kv2_GP_dend2_distal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv2_GP_dend2_proximal25compts})
        Kv2_GP_dend2_proximal25compts_tmpVal = {({getfield {mycompt}/Kv2_GP_dend2_proximal25compts Gbar})}
        KV2_dend_Gtot = {KV2_dend_Gtot} + {Kv2_GP_dend2_proximal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV2 {({getfield {mycompt}/Kv2_GP_dend2_proximal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv2_GP_dend1_distal25compts})
        Kv2_GP_dend1_distal25compts_tmpVal = {({getfield {mycompt}/Kv2_GP_dend1_distal25compts Gbar})}
        KV2_dend_Gtot = {KV2_dend_Gtot} + {Kv2_GP_dend1_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV2 {({getfield {mycompt}/Kv2_GP_dend1_distal25compts Gbar})}
        end
    end


// KV3

    if ({exists {mycompt}/Kv3_GP})
        Kv3_GP_tmpVal = {({getfield {mycompt}/Kv3_GP Gbar})}
        KV3_dend_Gtot = {KV3_dend_Gtot} + {Kv3_GP_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV3 {({getfield {mycompt}/Kv3_GP Gbar})}
        end
    end

    if ({exists {mycompt}/Kv3_GP_somahill})
        Kv3_GP_somahill_tmpVal = {({getfield {mycompt}/Kv3_GP_somahill Gbar})}
        KV3_soma_Gtot = {KV3_soma_Gtot} + {Kv3_GP_somahill_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV3 {({getfield {mycompt}/Kv3_GP_somahill Gbar})}
        end
    end

    if ({exists {mycompt}/Kv3_GP_dend3_distal25compts})
        Kv3_GP_dend3_distal25compts_tmpVal = {({getfield {mycompt}/Kv3_GP_dend3_distal25compts Gbar})}
        KV3_dend_Gtot = {KV3_dend_Gtot} + {Kv3_GP_dend3_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV3 {({getfield {mycompt}/Kv3_GP_dend3_distal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv3_GP_dend3_mid25compts})
        Kv3_GP_dend3_mid25compts_tmpVal = {({getfield {mycompt}/Kv3_GP_dend3_mid25compts Gbar})}
        KV3_dend_Gtot = {KV3_dend_Gtot} + {Kv3_GP_dend3_mid25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV3 {({getfield {mycompt}/Kv3_GP_dend3_mid25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv3_GP_dend3_proximal25compts})
        Kv3_GP_dend3_proximal25compts_tmpVal = {({getfield {mycompt}/Kv3_GP_dend3_proximal25compts Gbar})}
        KV3_dend_Gtot = {KV3_dend_Gtot} + {Kv3_GP_dend3_proximal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV3 {({getfield {mycompt}/Kv3_GP_dend3_proximal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv3_GP_dend2_distal25compts})
        Kv3_GP_dend2_distal25compts_tmpVal = {({getfield {mycompt}/Kv3_GP_dend2_distal25compts Gbar})}
        KV3_dend_Gtot = {KV3_dend_Gtot} + {Kv3_GP_dend2_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV3 {({getfield {mycompt}/Kv3_GP_dend2_distal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv3_GP_dend2_proximal25compts})
        Kv3_GP_dend2_proximal25compts_tmpVal = {({getfield {mycompt}/Kv3_GP_dend2_proximal25compts Gbar})}
        KV3_dend_Gtot = {KV3_dend_Gtot} + {Kv3_GP_dend2_proximal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV3 {({getfield {mycompt}/Kv3_GP_dend2_proximal25compts Gbar})}
        end
    end

    if ({exists {mycompt}/Kv3_GP_dend1_distal25compts})
        Kv3_GP_dend1_distal25compts_tmpVal = {({getfield {mycompt}/Kv3_GP_dend1_distal25compts Gbar})}
        KV3_dend_Gtot = {KV3_dend_Gtot} + {Kv3_GP_dend1_distal25compts_tmpVal}

        if ({echoGate} == 1)
            echo {mycompt} KV3 {({getfield {mycompt}/Kv3_GP_dend1_distal25compts Gbar})}
        end
    end

end

echo
echo NaF_soma_Gtot {NaF_soma_Gtot}
echo NaS_soma_Gtot {NaS_soma_Gtot}
echo KV2_soma_Gtot {KV2_soma_Gtot}
echo KV3_soma_Gtot {KV3_soma_Gtot}
echo NaF_dend_Gtot {NaF_dend_Gtot}
echo NaS_dend_Gtot {NaS_dend_Gtot}
echo KV2_dend_Gtot {KV2_dend_Gtot}
echo KV3_dend_Gtot {KV3_dend_Gtot}
echo

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