ModelDB is moving. Check out our new site at https://modeldb.science. The corresponding page is https://modeldb.science/137846.

GP Neuron, somatic and dendritic phase response curves (Schultheiss et al. 2011)

 Download zip file 
Help downloading and running models
Accession:137846
Phase response analysis of a GP neuron model showing type I PRCs for somatic inputs and type II PRCs for dendritic excitation. Analysis of intrinsic currents underlying type II dendritic PRCs.
Reference:
1 . Schultheiss NW, Edgerton JR, Jaeger D (2010) Phase response curve analysis of a full morphological globus pallidus neuron model reveals distinct perisomatic and dendritic modes of synaptic integration. J Neurosci 30:2767-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Oscillations; Synchronization; Active Dendrites; Synaptic Integration; Parkinson's; Phase Response Curves;
Implementer(s): Edgerton, Jeremy R. [jedgert at emory.edu]; Hanson, Jesse E.; Schultheiss, Nathan W [nwschultheiss at gmail.com]; 
// stimComptsNum reflects the number of compartments receiving a stimulus

str PRC_scale = "../common/comptlists/25compts_uniform_weights.txt"
//soma stimulus
if ({stimComptsIdx}==1)
    stimComptsNum = 1
    str strStimLoc = "_soma_"
    str PRCfilename = "../common/comptlists/nws_soma_only.txt"
    str PRC_scale = "../common/comptlists/soma_weight.txt"
end


//FULL (dendsort) dendrite divided into thirds of the range of electrotonic distances
if ({stimComptsIdx}==2)
    stimComptsNum = 247
    str strStimLoc = "proximal_FULL"
    str PRCfilename = "../common/comptlists/nws_proximal_FULLdendcompts.txt"
    if ({stimType}==2 || {stimType}==3)
        PRC_scale = "../common/comptlistsFULLproximal_uniform_weights.txt"
    end
    if ({stimType}==4 || {stimType}==5)
        PRC_scale = "../common/comptlists/FULLproximal_weights.txt"
    end
end

if ({stimComptsIdx}==3)
    stimComptsNum = 227
    str strStimLoc = "mid_FULL"
    str PRCfilename = "../common/comptlists/nws_mid_FULLdendcompts.txt"
    if ({stimType}==2 || {stimType}==3)
        PRC_scale = "../common/comptlists/FULLmid_uniform_weights.txt"
    end
    if ({stimType}==4 || {stimType}==5)
        PRC_scale = "../common/comptlists/FULLmid_weights.txt"
    end
end

if ({stimComptsIdx}==4)
    stimComptsNum = 37
    str strStimLoc = "distal_FULL"
    str PRCfilename = "../common/comptlists/nws_distal_FULLdendcompts.txt"
    if ({stimType}==2 || {stimType}==3)
        PRC_scale = "../common/comptlists/FULLdistal_uniform_weights.txt"
    end
    if ({stimType}==4 || {stimType}==5)
        PRC_scale = "../common/comptlists/FULLdistal_weights.txt"
    end
end


//THIRDS (dendsort) dendrite divided into thirds of compartments sorted by ED
if ({stimComptsIdx}==5)
    stimComptsNum = 171
    str strStimLoc = "proximal_THIRDS"
    str PRCfilename = "../common/comptlists/nws_proximal_THIRDSdendcompts.txt"
    if ({stimType}==2 || {stimType}==3)
        PRC_scale = "../common/comptlists/THIRDSproximal_uniform_weights.txt"
    end
    if ({stimType}==4 || {stimType}==5)
        PRC_scale = "../common/comptlists/THIRDSproximal_weights.txt"
    end
end

if ({stimComptsIdx}==6)
    stimComptsNum = 170
    str strStimLoc = "mid_THIRDS"
    str PRCfilename = "../common/comptlists/nws_mid_THIRDSdendcompts.txt"
    if ({stimType}==2 || {stimType}==3)
        PRC_scale = "../common/comptlists/THIRDSmid_uniform_weights.txt"
    end
    if ({stimType}==4 || {stimType}==5)
        PRC_scale = "../common/comptlists/THIRDSmid_weights.txt"
    end
end

if ({stimComptsIdx}==7)
    stimComptsNum = 170
    str strStimLoc = "distal_THIRDS"
    str PRCfilename = "../common/comptlists/nws_distal_THIRDSdendcompts.txt"
    if ({stimType}==2 || {stimType}==3)
        PRC_scale = "../common/comptlists/THIRDSdistal_uniform_weights.txt"
    end
    if ({stimType}==4 || {stimType}==5)
        PRC_scale = "../common/comptlists/THIRDSdistal_weights.txt"
    end
end


//SUB (dendsort) a random sample of 33 compartments chosen from THIRDS divisions
if ({stimComptsIdx}==8)
    stimComptsNum = 33
    str strStimLoc = "proximal_SUB"
    str PRCfilename = "../common/comptlists/nws_proximal_SUBdendcompts.txt"
    if ({stimType}==2 || {stimType}==3)
        PRC_scale = "../common/comptlists/SUBuniform33_weights.txt"
    end
    if ({stimType}==4 || {stimType}==5)
        PRC_scale = "../common/comptlists/SUBproximal_weights.txt"
    end
end

if ({stimComptsIdx}==9)
    stimComptsNum = 33
    str strStimLoc = "mid_SUB"
    str PRCfilename = "../common/comptlists/nws_mid_SUBdendcompts.txt"
    if ({stimType}==2 || {stimType}==3)
        PRC_scale = "../common/comptlists/SUBuniform33_weights.txt"
    end
    if ({stimType}==4 || {stimType}==5)
        PRC_scale = "../common/comptlists/SUBmid_weights.txt"
    end
end

if ({stimComptsIdx}==10)
    stimComptsNum = 33
    str strStimLoc = "distal_SUB"
    str PRCfilename = "../common/comptlists/nws_distal_SUBdendcompts.txt"
    if ({stimType}==2 || {stimType}==3)
        PRC_scale = "../common/comptlists/SUBuniform33_weights.txt"
    end
    if ({stimType}==4 || {stimType}==5)
        PRC_scale = "../common/comptlists/SUBdistal_weights.txt"
    end
end

Loading data, please wait...