HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011)

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Neuron mod files for the WT and F1449V Na+ currents from the paper: Kinetic Modeling of Nav1.7 Provides Insight Into Erythromelalgia-associated F1449V Mutation M. Gurkiewicz, A. Korngreen, S. Waxman, and A. Lampert. J.Neurophysiol. (2011). The parameters for the K65, K53 and K63 transitions were derived from microscopic reversibility relationships in the model.
1 . Gurkiewicz M, Korngreen A, Waxman SG, Lampert A (2011) Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. J Neurophysiol 105:1546-57 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Dorsal Root Ganglion (DRG) cell;
Channel(s): I Sodium;
Gap Junctions:
Gene(s): Nav1.7 SCN9A;
Simulation Environment: NEURON;
Model Concept(s): Nociception; Erythromelalgia;
Implementer(s): Gurkiewicz, Meron [gurkiewicz at];
Search NeuronDB for information about:  I Sodium;
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