HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011)

 Download zip file 
Help downloading and running models
Accession:138082
Neuron mod files for the WT and F1449V Na+ currents from the paper: Kinetic Modeling of Nav1.7 Provides Insight Into Erythromelalgia-associated F1449V Mutation M. Gurkiewicz, A. Korngreen, S. Waxman, and A. Lampert. J.Neurophysiol. (2011). The parameters for the K65, K53 and K63 transitions were derived from microscopic reversibility relationships in the model.
Reference:
1 . Gurkiewicz M, Korngreen A, Waxman SG, Lampert A (2011) Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. J Neurophysiol 105:1546-57 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Dorsal Root Ganglion (DRG) cell;
Channel(s): I Sodium;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.7 SCN9A;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Nociception; Erythromelalgia;
Implementer(s): Gurkiewicz, Meron [gurkiewicz at gmail.com];
Search NeuronDB for information about:  I Sodium;
 
/
FV
readme.txt
FVNaG3e.mod
WTNaG3e.mod
                            
File not selected

<- Select file from this column.
Loading data, please wait...