Mechanisms of magnetic stimulation of central nervous system neurons (Pashut et al. 2011)

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Transcranial magnetic stimulation (TMS) is a widely applied tool for probing cognitive function in humans and is one of the best tools for clinical treatments and interfering with cognitive tasks. Surprisingly, while TMS has been commercially available for decades, the cellular mechanisms underlying magnetic stimulation remain unclear. Here we investigate these mechanisms using compartmental modeling. We generated a numerical scheme allowing simulation of the physiological response to magnetic stimulation of neurons with arbitrary morphologies and active properties. Computational experiments using this scheme suggested that TMS affects neurons in the central nervous system (CNS) primarily by somatic stimulation.
1 . Pashut T, Wolfus S, Friedman A, Lavidor M, Bar-Gad I, Yeshurun Y, Korngreen A (2011) Mechanisms of magnetic stimulation of central nervous system neurons. PLoS Comput Biol 7:e1002022 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Squid axon;
Gap Junctions:
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Action Potential Initiation; Magnetic stimulation;
Implementer(s): Korngreen, Alon [alon.korngreen at]; Pashut, Tamar [tamar.pashut at];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell;
•	Open the file "demo.hoc"
•	Press "Init & Run" in the RunControl window. 
•	A movie presenting the membrane potential along the axon fiber will appear in the Graph[3] window. Notice that the stimulation amplitude default is set to 30 volts agreeing with the subthreshold activity.    
•	You can control the electrical circuit and stimulation parameters in the Magnetic Coil Current window. Changing the stimulation amplitude to a value higher than 36 volt will present a superthreshold activity.
•	In addition to the movie graph, the pulse shape is presented in Graph window and the membrane potential in the soma as a function of time is presented in Graph[2].   

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