Reconstructing cerebellar granule layer evoked LFP using convolution (ReConv) (Diwakar et al. 2011)

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Accession:139883
The model allows reconstruction of evoked local field potentials as seen in the cerebellar granular layer. The approach uses a detailed model of cerebellar granule neuron to generate data traces and then uses a "ReConv" or jittered repetitive convolution technique to reproduce post-synaptic local field potentials in the granular layer. The algorithm was used to generate both in vitro and in vivo evoked LFP and reflected the changes seen during LTP and LTD, when such changes were induced in the underlying neurons by modulating release probability of synapses and sodium channel regulated intrinsic excitability of the cells.
Reference:
1 . Diwakar S, Lombardo P, Solinas S, Naldi G, D'Angelo E (2011) Local field potential modeling predicts dense activation in cerebellar granule cells clusters under LTP and LTD control. PLoS One 6:e21928 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I K; I M; I K,Ca; I Sodium; I Calcium; I Cl, leak;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB; Octave;
Model Concept(s): Extracellular Fields; Evoked LFP;
Implementer(s): Diwakar, Shyam [shyam at amrita.edu];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; GabaA; AMPA; NMDA; I K; I M; I K,Ca; I Sodium; I Calcium; I Cl, leak;
 
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ReConv
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Invitro
Invivo
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