Shaping of action potentials by different types of BK channels (Jaffe et al., 2011)

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Accession:140471
Dentate gyrus granule cells highly express the beta4 accessory subunit which confer BK channels with type II properties. The properties of heterologously-expressed BK channels (with and without the beta4 subunit) were used to construct channel models. These were then used to study how they affect single action potentials and trains of spikes in a model dentate gyrus granule cells (based on Aradi and Holmes, 1999).
Reference:
1 . Jaffe DB, Wang B, Brenner R (2011) Shaping of action potentials by type I and type II large-conductance Ca²+-activated K+ channels. Neuroscience 192:205-18 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s): I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Jaffe, David B [david.jaffe at utsa.edu];
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; I K,Ca;
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28.85 -76.033 7e-05 0.000602575
28.875 -76.0293 7e-05 0.000599067
28.9 -76.0256 7e-05 0.000595579
28.925 -76.022 7e-05 0.000592111
28.95 -76.0183 7e-05 0.000588663
28.975 -76.0146 7e-05 0.000585235
29 -76.0109 7e-05 0.000581827
29.025 -76.0072 7e-05 0.000578438
29.05 -76.0036 7e-05 0.000575069
29.075 -75.9999 7e-05 0.000571719
29.1 -75.9962 7e-05 0.000568389
29.125 -75.9926 7e-05 0.000565078
29.15 -75.9889 7e-05 0.000561785
29.175 -75.9852 7e-05 0.000558512
29.2 -75.9816 7e-05 0.000555258
29.225 -75.9779 7e-05 0.000552022
29.25 -75.9742 7e-05 0.000548806
29.275 -75.9706 7e-05 0.000545607
29.3 -75.9669 7e-05 0.000542427
29.325 -75.9633 7e-05 0.000539266
29.35 -75.9596 7e-05 0.000536122
29.375 -75.956 7e-05 0.000532997
29.4 -75.9523 7e-05 0.00052989
29.425 -75.9487 7e-05 0.000526801
29.45 -75.945 7e-05 0.000523729
29.475 -75.9414 7e-05 0.000520675
29.5 -75.9378 7e-05 0.000517639
29.525 -75.9341 7e-05 0.00051462
29.55 -75.9305 7e-05 0.000511619
29.575 -75.9269 7e-05 0.000508635
29.6 -75.9232 7e-05 0.000505669
29.625 -75.9196 7e-05 0.000502719
29.65 -75.916 7e-05 0.000499786
29.675 -75.9123 7e-05 0.000496871
29.7 -75.9087 7e-05 0.000493972
29.725 -75.9051 7e-05 0.00049109
29.75 -75.9015 7e-05 0.000488224
29.775 -75.8978 7e-05 0.000485376
29.8 -75.8942 7e-05 0.000482543
29.825 -75.8906 7e-05 0.000479727
29.85 -75.887 7e-05 0.000476927
29.875 -75.8834 7e-05 0.000474143
29.9 -75.8798 7e-05 0.000471376
29.925 -75.8762 7e-05 0.000468624
29.95 -75.8726 7e-05 0.000465889
29.975 -75.869 7e-05 0.000463169

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