Hippocampal CA3 network and circadian regulation (Stanley et al. 2013)

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Accession:142104
This model produces the hippocampal CA3 neural network model used in the paper below. It has two modes of operation, a default mode and a circadian mode. In the circadian mode, parameters are swept through a range of values. This model can be quite easily adapted to produce theta and gamma oscillations, as certain parameter sweeps will reveal (see Figures). BASH scripts interact with GENESIS 2.3 to implement parameter sweeps. The model contains four cell types derived from prior papers. CA3 pyramidal are derived from Traub et al (1991); Basket, stratum oriens (O-LM), and Medial Septal GABAergic (MSG) interneurons are taken from Hajos et al (2004).
Reference:
1 . Stanley DA, Talathi SS, Parekh MB, Cordiner DJ, Zhou J, Mareci TH, Ditto WL, Carney PR (2013) Phase shift in the 24-hour rhythm of hippocampal EEG spiking activity in a rat model of temporal lobe epilepsy. J Neurophysiol 110:1070-86 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus; Medial Septum;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Hippocampus septum medial GABAergic neuron;
Channel(s): I Na,t; I A; I K; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS; MATLAB;
Model Concept(s): Epilepsy; Brain Rhythms; Circadian Rhythms;
Implementer(s): Stanley, David A ;
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; GabaA; AMPA; I Na,t; I A; I K; I h; I K,Ca; I Calcium; Gaba; Glutamate;




include traub91proto.g

if (!({exists /library}))
	create neutral /library
end

create neutral /library_traub91
pushe /library_traub91
//    make_cylind_symcompartment  /* makes "symcompartment" */
create symcompartment symcompartment
/* Assign some constants to override those used in traub91proto.g */
EREST_ACT = -0.06       // resting membrane potential (volts)
float ENA = 0.115 + EREST_ACT // 0.055  when EREST_ACT = -0.060
float EK = -0.015 + EREST_ACT // -0.075
float ECA = 0.140 + EREST_ACT // 0.080

make_Na
make_Ca
make_K_DR
make_K_AHP
make_K_C
make_K_A
make_Ca_conc

pope


move /library /library_temp
move /library_traub91 /library

//readcell CA3_traub91_reduced_Ca.p /prot_pyr
readcell CA3_traub91_orig.p /prot_pyr

move /library /library_traub91
move /library_temp /library

disable /library_traub91


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