CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)

 Download zip file 
Help downloading and running models
NEURON files from the paper: On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons by D.Bianchi, A. Marasco, A.Limongiello, C.Marchetti, H.Marie,B.Tirozzi, M.Migliore (2012). J Comput. Neurosci. In press. DOI: 10.1007/s10827-012-0383-y. Experimental findings shown that under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. We analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specic ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to depolarization block.
1 . Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012) On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons. J Comput Neurosci 33:207-25 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Mathematica;
Model Concept(s): Simplified Models; Depolarization block; Bifurcation;
Implementer(s): Bianchi, Daniela [danielabianchi12 -at-]; Limongiello, Alessandro [alessandro.limongiello at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; AMPA; NMDA; I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP; Gaba; Glutamate;
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
n123.hoc *
oblique-paths.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
// This function makes a list with oblique branches in addition to 
// the primary list in apical-tip-list.hoc 
// written by Yiota Poirazi, July 2001,

objref apical_tip_list_addendum
apical_tip_list_addendum=new SectionList()

//    SISTER of apical_dendrite[3]   is apical_dendrite[2]    
//    SISTER of apical_dendrite[34]  is apical_dendrite[33]   
//    SISTER of apical_dendrite[37]  is apical_dendrite[36]   
//    SISTER of apical_dendrite[40]  is apical_dendrite[39]
//    SISTER of apical_dendrite[45]  is apical_dendrite[44]
//    SISTER of apical_dendrite[54]  is apical_dendrite[53] 
//    SISTER of apical_dendrite[68]  is apical_dendrite[67] 
//    SISTER of apical_dendrite[111] is apical_dendrite[110] 
//    SISTER of apical_dendrite[115] is apical_dendrite[114] 
//    SISTER of apical_dendrite[118] is apical_dendrite[117] 

  apical_dendrite[2]    apical_tip_list_addendum.append()  // 1 degree      69.9821  microns from soma
  apical_dendrite[33]   apical_tip_list_addendum.append()  // 2 degrees    177.4831 (vertical distance)
  apical_dendrite[36]   apical_tip_list_addendum.append()  // 2 degree     189.0447 
  apical_dendrite[37]   apical_tip_list_addendum.append()  // 2 degrees    180.5792 
  apical_dendrite[39]   apical_tip_list_addendum.append()  // 1 degree      83.7030
  apical_dendrite[40]   apical_tip_list_addendum.append()  // 1 degreee    102.6654
  apical_dendrite[44]   apical_tip_list_addendum.append()  // 0 degree     172.7760 
  apical_dendrite[47]   apical_tip_list_addendum.append()  // 0 degree.    177.4980
  apical_dendrite[53]   apical_tip_list_addendum.append()  // 3 degrees    202.8910
  apical_dendrite[54]   apical_tip_list_addendum.append()  // 3 degrees    190.3009
  apical_dendrite[67]   apical_tip_list_addendum.append()  // 2 degrees    289.5367   
  apical_dendrite[110]  apical_tip_list_addendum.append()  // 1 degree      98.7392
  apical_dendrite[114]  apical_tip_list_addendum.append()  // 1 degree     123.9962
  apical_dendrite[117]  apical_tip_list_addendum.append()  // 0 degree      67.6363

//  forsec apical_tip_list_addendum {
//    apical_tip_list.append()
//  }

/* Make a shape graph with the additional oblique branches

objref apical_tip_list_addendum_shape
color_index = 3
apical_tip_list_addendum_shape=new Shape()

Loading data, please wait...