Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)

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Accession:144372
Three models of increasing complexity all showing a switch from type II (biphasic) to type I (monophasic) phase response curves with a cholinergic down-modulation of K+ conductances.
Reference:
1 . Stiefel KM, Gutkin BS, Sejnowski TJ (2009) The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons. J Comput Neurosci 26:289-301 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I M;
Gap Junctions:
Receptor(s): Muscarinic;
Gene(s):
Transmitter(s): Acetylcholine;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Stiefel, Klaus [stiefel at salk.edu];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; Muscarinic; I Na,p; I Na,t; I M; Acetylcholine;
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StiefelEtAl2009
README.txt
ca.mod *
cacum.mod
cad.mod *
H.mod
iahp2.mod *
il.mod *
im.mod *
KA.mod
kca.mod *
Kdr.mod
km.mod *
Ks.mod
kv.mod *
Na.mod *
NaP.mod
cell.ses
displayshape.hoc
fig4A.hoc
fig4A_new.hoc
fig5A.hoc
fig5B.hoc
fig5C.hoc
gui.hoc
j8.hoc *
ksprc.ses
makeIF.hoc
multi.hoc
PRC.hoc
PRCsweep.hoc
PY-golomb_original.hoc
PY-golomb_plus.hoc
PY-golomb_simple.hoc
PyMainen.hoc
single.hoc
single_plus.hoc
single1.ses
surface.hoc
synproxy_cch.hoc
synproxy_sweeps.hoc
                            
/******************************************************************************
   One compartment pyramidal cell
  
   Based on: 
   Golomb D, Amitai Y (1997) Propagating neuronal discharges in
   neocortical slices: computational and experimental study. J Neurophys
   78: 1199-1211.
 
   Arthur Houweling
******************************************************************************/


create soma
access soma

cm= 1
diam= L= sqrt( 25000/ PI)   

insert pas
insert Na
insert NaP
insert Kdr
insert KA
insert Ks
insert H

e_pas= -70		
ena=    55
ek=    -90
e_H=   -40

g_pas=        2e-5			
g_Na= 	0.024
g_NaP=	      7e-5
g_Kdr=  0.003
g_KA=   0.0014
g_Ks=   0.002			// Golomb's value 0.001
g_H=	      2e-5

//---------------------------------------------------------------------
// Other parameters
//---------------------------------------------------------------------

v_init= -70.93
dt= 0.025
celsius= 36
steps_per_ms= 5


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