Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)

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Accession:144372
Three models of increasing complexity all showing a switch from type II (biphasic) to type I (monophasic) phase response curves with a cholinergic down-modulation of K+ conductances.
Reference:
1 . Stiefel KM, Gutkin BS, Sejnowski TJ (2009) The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons. J Comput Neurosci 26:289-301 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I M;
Gap Junctions:
Receptor(s): Muscarinic;
Gene(s):
Transmitter(s): Acetylcholine;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Stiefel, Klaus [stiefel at salk.edu];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; Muscarinic; I Na,p; I Na,t; I M; Acetylcholine;
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StiefelEtAl2009
README.txt
ca.mod *
cacum.mod
cad.mod *
H.mod
iahp2.mod *
il.mod *
im.mod *
KA.mod
kca.mod *
Kdr.mod
km.mod *
Ks.mod
kv.mod *
Na.mod *
NaP.mod
cell.ses
displayshape.hoc
fig4A.hoc
fig4A_new.hoc
fig5A.hoc
fig5B.hoc
fig5C.hoc
gui.hoc
j8.hoc *
ksprc.ses
makeIF.hoc
multi.hoc
PRC.hoc
PRCsweep.hoc
PY-golomb_original.hoc
PY-golomb_plus.hoc
PY-golomb_simple.hoc
PyMainen.hoc
single.hoc
single_plus.hoc
single1.ses
surface.hoc
synproxy_cch.hoc
synproxy_sweeps.hoc
                            
// Fig 5C

objref cchhere
cchhere = new SectionList()

// all sections where change should occur:

access a2_12
cchhere.append()
access a2_122
cchhere.append()
access a2_1222
cchhere.append()
access a2_12222
cchhere.append()
access a2_12221
cchhere.append()
access a2_121122
cchhere.append()
access a2_121121
cchhere.append()
access a2_1211212
cchhere.append()
access a2_12112122
cchhere.append()
access a2_1211211
cchhere.append()
access a2_12112121
cchhere.append()
access a2_121
cchhere.append()
access a2_1211
cchhere.append()
access a2_1212
cchhere.append()
access a2_121211
cchhere.append()
access a2_121212
cchhere.append()
access a2_12122
cchhere.append()

access soma

objref ii
soma ii = new IClamp(.5)
ii.del=0
ii.amp=0.05
ii.dur=2000

//
// low carbachol in one dendritic tree, high carbachol in the rest of the cell.
//

// high carbachol
	forsec dendritic {
		g_pas 	= 1.8e-5
		e_pas 	= -58
		gbar_km	=  2*0.05
		gbar_kca = 3*0
		}				
forall {gbar_na=gbar_na*0.55}

// low carbachol
forsec cchhere{
		g_pas 	= 1.8e-5
		e_pas 	= -58
		gbar_km	=  2*0.9
		gbar_kca = 3*0.25
		gbar_na = 20
		}
				
 for synnr = 2, 3 {
	for aa= 0, 3 {spikesin[aa].weight = 0}
	if (synnr == 0) { spikesin[synnr].weight = 0.01 }  else { spikesin[synnr].weight = 0.05 }
	makeprc()
}

/*
//
// low carbachol in one dendritic tree, none in the rest of the cell.
//

ii.amp=0.15

// no carbachol
forsec dendritic {
		g_pas 	= 2e-5
		e_pas 	= -60
		gbar_km	=  2
		gbar_kca = 3
		}

// low carbachol
forsec cchhere {
		g_pas 	= 1.8e-5
		e_pas 	= -58
		gbar_km	=  2*0.9
		gbar_kca = 3*0.25
		}
		
 for synnr = 2, 3 {
	for aa= 0, 3 {spikesin[aa].weight = 0}
	if (synnr == 0) { spikesin[synnr].weight = 0.01 }  else { spikesin[synnr].weight = 0.05 }
	makeprc()
}

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