ModelDB: Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)

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Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)

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Accession:144372

Three models of increasing complexity all showing a switch from type II (biphasic) to type I (monophasic) phase response curves with a cholinergic down-modulation of K+ conductances.
Reference:
1 . Stiefel KM, Gutkin BS, Sejnowski TJ (2009) The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons. J Comput Neurosci 26:289-301 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:
Brain Region(s)/Organism:
Cell Type(s):	Neocortex L2/3 pyramidal GLU cell;
Channel(s):	I Na,p; I Na,t; I M;
Gap Junctions:
Receptor(s):	Muscarinic;
Gene(s):
Transmitter(s):	Acetylcholine;
Simulation Environment:	NEURON;
Model Concept(s):	Action Potentials;
Implementer(s):	Stiefel, Klaus [stiefel at salk.edu];

Search NeuronDB for information about: Neocortex L2/3 pyramidal GLU cell; Muscarinic; I Na,p; I Na,t; I M; Acetylcholine;

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PY-golomb_original.hoc

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