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CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
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NEURON mod files from the paper: Shah et al., 2011. In this study, using a combination of electrophysiology and computational modelling, we show that these channels selectively influence peri-somatic but not dendritic post-synaptic excitatory synaptic potential (EPSP) integration in CA1 pyramidal cells. This may be important for their relative contributions to physiological processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy.
Shah MM, Migliore M, Brown DA (2011) Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons.
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
Migliore, Michele [Michele.Migliore at Yale.edu];
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Hippocampus CA1 pyramidal GLU cell
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