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\begin{document}
% As part of our efforts to improve published figure quality, we
% recommend that you size your figures to fit one of three widths;
% 8.3cm, 12.35cm, or 17.35cm wide (maximum figure height is 23.35 cm),
% as detailed in our Figure Guidelines at
% http://www.ploscompbiol.org/static/figureGuidelines.action#quickref.
\fontsize{8}{20}\selectfont
% \section{Main plots}
% \label{plots:sec:main-plots}
\figtitle{Figure 1}
% : Experimental and model responses to somatic current
% injection.
\vspace{\baselineskip}
%\includegraphics[width=0.8\linewidth]{figure1_version2010_08_27cell2_withfit-r150}
\noindent\includegraphics{../../journal-paper/figures/figure1a}
\begin{minipage}[b]{0.5\colwidth}
\includegraphics{../../journal-paper/figures/Fig2009_10_26cell1_1sp_withfit}
\includegraphics{../../journal-paper/figures/relcalcium}
%\includegraphics{relcalcium}
\end{minipage}
\includegraphics{somainj-manual2}
\includegraphics{\dg ca1_poirazi-somainj-Ra050-cv1-synrecs}
% \textbf{A} Experimnentally-measured calcium fluorescence
% traces from the apical trunk. \textbf{B} Height of fluorescnece peak
% versus distance from the soma. \textbf{C} Top trace: time course of
% membrane potential at coloured spines and soma (black). Middle trace:
% time course of calcium concentration in the dendritic tree next to the
% coloured spines. Bottom trace: time course of calcium concentration in
% coloured spine heads. \textbf{D} peak value of the membrane potential
% throughout the tree. \textbf{E} Peak value of calcium concentration
% throughout the tree.
\pagebreak[4]
\figtitle{Figure 2}
% : Response to Schaffer collateral stimulation by 240
% synchronously-activated synapses.
\vspace{\baselineskip}
\noindent
\begin{minipage}[t]{0.5\colwidth}
\textbf{A}\\
\includegraphics[width=\linewidth]{dendburst}
\end{minipage}
\begin{minipage}[t]{0.5\colwidth}
\mbox{}\\[-0.5\baselineskip]
\includegraphics{\dg ca1_poirazi-dendburst-s240-j00t1-a200-n45-bv-r170-sc0-Ra050-nr0100-cv1-synrecs}
\end{minipage}\\
\noindent\includegraphics{\dg ca1_poirazi-dendburst-s240-j00t1-a200-n45-bv-r170-sc0-Ra050-nr0100-cv1}
% \textbf{A} Morphology of simulated
% cell, including positions of synapses (in gray). Panels
% \textbf{B--E} show representative traces of membrane potential
% (\textbf{B}), calcium concentration (\textbf{C}), NMDA current
% (\textbf{D}) and AMPA current (\textbf{E}). Panels \textbf{F-I} show
% statistics of the membrane potential and calcium traces, averaged
% over 100 runs. On each run, the locations of all spines apart from
% the coloured reference spines was generated randomly according to
% the realistic statistics (see Methods). In each case, the black line
% shows the regression of path distance on the quantity in question,
% and the $R^2$ value for the fit is quoted. Vertical lines indicate
% the standard deviation. \textbf{F} Amplitude of membrane potential
% at peak. \textbf{G} Amplitude of calcium concentration at peak. In
% both the amplitude plots there is very little variability in
% amplitude between trials. \textbf{H} Delay from stimulation to peak
% membrane potential. \textbf{I} Delay from stimulation to peak
% calcium concentration. In both the delay plots, the grey vertical
% lines indicate significant variability.
\pagebreak[4]
Figure 3
\pagebreak[4]
\noindent\figtitle{Figure 4}
% : \textbf{(A-D)}~The effect of asynchronous inputs on
% features of voltage and calcium signals. \textbf{(E-L)}~The effect of
% subthreshold input on features of voltage and calcium signals.
\vspace{\baselineskip}
\noindent\includegraphics{\dg ca1_poirazi-dendburst-s240-j10t1-a200-n45-bv-r170-sc0-Ra050-nr0100-cv1}\\
\noindent\includegraphics{\dg ca1_poirazi-dendburst-s190-j00t1-a200-n45-bv-r170-sc0-Ra050-nr0100-cv1}
% (A-D) The effect of asynchronous inputs on features of voltage and
% calcium signals. In each of 100 simulations, the cell was
% presented with synaptic inputs whose activation times were
% randomly drawn from a 10ms window. The average values of the
% features plotted against distance. (E-L) The effect of
% subthreshold input on features of voltage and calcium signals. In
% this simulation 190 synapses were activated, which was not
% sufficient to bring the neuron to its firing threshold. In all
% other respects the simulation was the same as that shown in Fig
% 2. (E-H) Traces of membrane potential, calcium concentration,
% calcium current and block factor from the coloured synapses in
% Figure 2A. (I-L) Peak value and delay to peak of voltage and
% calcium signals.
\pagebreak[4]
Figure 5
\pagebreak[4]
\figtitle{Figure 6}
% : Features of calcium and voltage signals as
% predictors of attenuation.
\vspace{\baselineskip}
\noindent\includegraphics{\dg att-dist}
\includegraphics{\dg ca1_poirazi-dendburst-s240-j00t1-a200-n45-bv-r170-sc0-Ra050-nr0100-cv1-att}
% Features of calcium and voltage signals as predictors of
% attenuation. (A) Path distance between soma and synapse versus EPSP
% attenuation at the soma. (B-E) With synchronous Schaffer Collateral
% input, features of the time course of the voltage and calcium
% signals plotted against attenuation rather than distance as in
% Figure 2F-I.
\pagebreak[4]
\figtitle{Figure 7}
\vspace{\baselineskip}
\includegraphics{\dg ca1_poirazi-dendburst-s240-j00t1-a200-n45-bv-r170-sc1-Ra050-nr0100-cv1}
\pagebreak[4]
Figure 8
\pagebreak[4]
\figtitle{Figure S1}
\includegraphics{stimulation-comparison}
\pagebreak[4]
Figure S2
\pagebreak[4]
\figtitle{Figure S3}
\noindent
\begin{minipage}[t]{0.5\colwidth}
\textbf{A}\\
\includegraphics[width=\linewidth]{dendburst}
\end{minipage}
\begin{minipage}[t]{0.5\colwidth}
\mbox{}\\[-0.5\baselineskip]
\includegraphics{\dg ca1_poirazi-dendburst-s240-j00t1-a200-n45-bv-r000-sc0-Ra050-nr0100-cv1-synrecs}
\end{minipage}\\
\noindent\includegraphics{\dg ca1_poirazi-dendburst-s240-j00t1-a200-n45-bv-r000-sc0-Ra050-nr0100-cv1}
\pagebreak[4]
Figure S4
\end{document}
% LocalWords: NMDA AMPA EPSP
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