CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)

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Accession:144490
This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Reference:
1 . Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy. PLoS Comput Biol 8:e1002545 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Synaptic Plasticity;
Implementer(s): Sterratt, David ; Groen, Martine R [martine.groen at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I Mixed; I R; I_AHP;
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bpap
plots
Makefile
plots.tex
vc
vc-git.awk
                            
#!/bin/sh
# This is file 'vc' from the vc bundle for TeX.
# The original file can be found at CTAN:support/vc.
# This file is Public Domain.

# Parse command line options.
full=0
mod=0
while [ -n "$(echo $1 | grep '-')" ]; do
    case $1 in 
       -f ) full=1 ;;
       -m ) mod=1 ;;
       *  ) echo 'usage: vc [-f] [-m]'
            exit 1
    esac
    shift
done
# English locale.
LC_ALL=C
git --no-pager log -1 HEAD --pretty=format:"Hash: %H%nAbr. Hash: %h%nParent Hashes: %P%nAbr. Parent Hashes: %p%nAuthor Name: %an%nAuthor Email: %ae%nAuthor Date: %ai%nCommitter Name: %cn%nCommitter Email: %ce%nCommitter Date: %ci%n" |gawk -v script=log -v full=$full -f vc-git.awk > vc.tex
if [ "$mod" = 1 ]
then
  git status |gawk -v script=status -f vc-git.awk >> vc.tex
fi

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