ModelDB: CA1 pyramidal neuron: Ih current (Migliore et al. 2012)

CA1 pyramidal neuron: Ih current (Migliore et al. 2012)

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Accession:144541

NEURON files from the paper: Migliore M, Migliore R (2012) Know Your Current Ih: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations. PLoS ONE 7(5): e36867. doi:10.1371/journal.pone.0036867. Experimental findings on the effects of Ih current modulation, which is particularly involved in epilepsy, appear to be inconsistent. In the paper, using a realistic model we show how and why a shunting current, such as that carried by TASK-like channels, dependent on the Ih peak conductance is able to explain virtually all experimental findings on Ih up- or down-regulation by modulators or pathological conditions.
Reference:
1 . Migliore M, Migliore R (2012) Know your current I(h): interaction with a shunting current explains the puzzling effects of its pharmacological or pathological modulations. PLoS One 7:e36867 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Synapse; Channel/Receptor;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I A; I K; I M; I h; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Detailed Neuronal Models; Epilepsy; Synaptic Integration;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];