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CA1 pyramidal neuron: Ih current (Migliore et al. 2012)
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NEURON files from the paper: Migliore M, Migliore R (2012) Know Your Current Ih: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations. PLoS ONE 7(5): e36867. doi:10.1371/journal.pone.0036867. Experimental findings on the effects of Ih current modulation, which is particularly involved in epilepsy, appear to be inconsistent. In the paper, using a realistic model we show how and why a shunting current, such as that carried by TASK-like channels, dependent on the Ih peak conductance is able to explain virtually all experimental findings on Ih up- or down-regulation by modulators or pathological conditions.
Migliore M, Migliore R (2012) Know your current I(h): interaction with a shunting current explains the puzzling effects of its pharmacological or pathological modulations.
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Hippocampus CA1 pyramidal GLU cell;
Detailed Neuronal Models;
Migliore, Michele [Michele.Migliore at Yale.edu];
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Hippocampus CA1 pyramidal GLU cell
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