NMDA subunit effects on Calcium and STDP (Evans et al. 2012)

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Accession:145917
Effect of NMDA subunit on spike timing dependent plasticity.
Reference:
1 . Evans RC, Morera-Herreras T, Cui Y, Du K, Sheehan T, Kotaleski JH, Venance L, Blackwell KT (2012) The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS Comput Biol 8:e1002493 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): STDP; Calcium dynamics;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; GabaA; Glutamate; I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
//genesis
//  K_DR_channel.g

/***************************		MS Model, Version 7.6	*********************
**************************** 	      K_DR_channel.g  	*********************
	Avrama Blackwell 	kblackw1@gmu.edu
	Rebekah Evans 		rcolema2@gmu.edu	
	Tom Sheehan 		tsheeha2@gmu.edu	
******************************************************************************

*****************************************************************************/

//************************ Begin Primary Routine ******************************
//*****************************************************************************
function make_K_DR_channel
	//********************* Begin Local Variables ******************************
   float xmin = -0.1
   float xmax = 0.05
   int xdivs = 3000
   float x,dx,alpha_m,beta_m,tau_m,m_inf,a_slope,b_slope,a_vhalf,b_vhalf
   int i
   float Erev = -0.09    
	//********************* End Local Variables ********************************

 	if ({exists K_DR})
		echo "K_DR tabchannel exists"
   	return
 	end
 
 	create tabchannel K_DR 
  	setfield ^ Ek {Erev} 	\
             Gbar 100.0 	\ 
             Ik 0        	\
             Gk 0        	\
             Xpower 1    	\
             Ypower 0    	\
             Zpower 0 

  	call K_DR TABCREATE X {xdivs} {xmin} {xmax}
        dx = (xmax-xmin)/xdivs
        x = xmin
//	echo "K_DR increment:" {dx} "V"
	float a_vhalf=-0.013
    float b_vhalf=-0.013
	float a_slope=-0.00909
	float b_slope=-0.0125
echo "make KDR, qfactor=" {qfactorKDR}	
	for (i=0;i<={xdivs};i=i+1)

		/*migliore, et,al 1999 */
	  alpha_m =({exp {(x-{a_vhalf})/{a_slope}}} )
      beta_m  =({exp {(x-{b_vhalf})/{b_slope}}}) 
      tau_m = {{0.001*50*beta_m/(1+alpha_m)}/qfactorKDR}
      m_inf = 1/(1+alpha_m)
      setfield K_DR X_A->table[{i}] {tau_m}
      setfield K_DR X_B->table[{i}] {m_inf}
      x = x+dx
   end

   tweaktau K_DR X 
 
   setfield K_DR X_A->calc_mode 1 X_B->calc_mode 1
end
//************************ End Primary Routine ********************************
//*****************************************************************************

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