NMDA subunit effects on Calcium and STDP (Evans et al. 2012)

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Accession:145917
Effect of NMDA subunit on spike timing dependent plasticity.
Reference:
1 . Evans RC, Morera-Herreras T, Cui Y, Du K, Sheehan T, Kotaleski JH, Venance L, Blackwell KT (2012) The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS Comput Biol 8:e1002493 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): STDP; Calcium dynamics;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; GabaA; Glutamate; I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
//genesis
//  SKchannelCaDep.g

/***************************		MS Model, Version 7.6	*********************
**************************** 	      SKchannelCaDep.g  	*********************
	Avrama Blackwell 	kblackw1@gmu.edu
	Rebekah Evans 		rcolema2@gmu.edu	
	Tom Sheehan 		tsheeha2@gmu.edu	
******************************************************************************

*****************************************************************************/

function make_SK_channel

  	int i	= 5
  	int nStep = 1000
  	float SKact = 0.0
  	float CaMax = 0.002
	float theta = 0.0
	float theta_pow = 0.0	
  	float CaMax = 0.002
  	int nStep = 1000
  	float Kd = 0.57e-003
  	float delta = 0.0001
   int y = 1
   float x = 0.0
    		
  	str chanpath = "SK_channel" 
  	
  	pushe /library

  	if (({exists {chanpath}}))
    	return
  	end

  	create  tabchannel {chanpath}
  	setfield	^		Ek  		{-90e-3}		\
					Gbar		0.145e4		\
					Ik			0			\
					Gk			0			\
					Xpower  	0			\
					Ypower  	0			\
					Zpower  	1			

  	call {chanpath} TABCREATE Z {nStep-1} 0 {CaMax} // Creates nCaSteps entries
	
	while(i > 0)
		i = 0
	end
	
	for (i = 0; i < {nStep}; i = i + 1)		 		
  		//let x = Ca; set the value for x 		
  		if(i < 26)
  			x = 0.0
  		else
  			if(y < 51)
  				x = delta
  				y = y + 1
  			else
  				y = 1
  				delta = delta + 0.0001
  			end
  		end 
  		theta = {x/Kd}
  		theta_pow = { pow {theta} 5.4}
  		SKact = theta_pow/{1 + theta_pow}
     	setfield {chanpath} Z_B->table[{i}] {SKact}
		setfield {chanpath} Z_A->table[{i}] {4e-3} // Fast component, tau=4ms
	end		   	  		 			 
  	tweaktau {chanpath} Z
  	pope
end






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