NMDA subunit effects on Calcium and STDP (Evans et al. 2012)

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Accession:145917
Effect of NMDA subunit on spike timing dependent plasticity.
Reference:
1 . Evans RC, Morera-Herreras T, Cui Y, Du K, Sheehan T, Kotaleski JH, Venance L, Blackwell KT (2012) The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS Comput Biol 8:e1002493 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): STDP; Calcium dynamics;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; GabaA; Glutamate; I Na,t; I L high threshold; I T low threshold; I A; I h; I K,Ca; I Calcium; I A, slow;
//genesis
//gaba_channel.g

function make_GABA_channel

   str chanpath = "GABA_channel"
   // From Galarreta and Hestrin 1997 (used in Wolfs model)
   float tau1 = 0.25e-3
   float tau2 = 3.75e-3

   float gmax = 750e-12  //Modified Koos 2004 (Wolf uses 435e-12)
   float Ek = -0.060

	echo "XXXXXXXXXXXXXXX make_GABA_channel XXXXXXXXXXXXXXXX"
	echo "XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX"
	echo "XXXXXXXXXXXXXXX make_GABA_channel XXXXXXXXXXXXXXXX"

   create synchan {chanpath}

   setfield {chanpath} tau1 {tau1} \
                       tau2 {tau2}\ 
                       gmax {gmax}\
                        Ek {Ek}

end



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