ModelDB: Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)

Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)

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Accession:146376

"... Here we introduce a new, automatic and fast method to map realistic neurons into equivalent reduced models running up to >40 times faster while maintaining a very high accuracy of the membrane potential dynamics during synaptic inputs, and a direct link with experimental observables. The mapping of arbitrary sets of synaptic inputs, without additional fine tuning, would also allow the convenient and efficient implementation of a new generation of large-scale simulations of brain regions reproducing the biological variability observed in real neurons, with unprecedented advances to understand higher brain functions."
Reference:
1 . Marasco A, Limongiello A, Migliore M (2012) Fast and accurate low-dimensional reduction of biophysically detailed neuron models. Sci Rep 2:928 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s):	AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Simplified Models; Detailed Neuronal Models;
Implementer(s):	Limongiello, Alessandro [alessandro.limongiello at unina.it];