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Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
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"... Here we introduce a new, automatic and fast method to map realistic neurons into equivalent reduced models running up to >40 times faster while maintaining a very high accuracy of the membrane potential dynamics during synaptic inputs, and a direct link with experimental observables. The mapping of arbitrary sets of synaptic inputs, without additional fine tuning, would also allow the convenient and efficient implementation of a new generation of large-scale simulations of brain regions reproducing the biological variability observed in real neurons, with unprecedented advances to understand higher brain functions."
Marasco A, Limongiello A, Migliore M (2012) Fast and accurate low-dimensional reduction of biophysically detailed neuron models.
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Hippocampus CA1 pyramidal GLU cell;
Detailed Neuronal Models;
Limongiello, Alessandro [alessandro.limongiello at unina.it];
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Hippocampus CA1 pyramidal GLU cell
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CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
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