This is a systems pharmacology model of the mammalian circadian clock
including PF-670462 developed in the paper:
Jae Kyoung Kim, Daniel B Forger, Michael Marconi, Douglas Wood, Angela
Doran, Travis Wager, Cheng Chang, and Kevin M Walton (2013) "Modeling
and validating chronic pharmacological manipulation of circadian
rhythms", CPT: Pharmacometrics & Systems Pharmacology.
The model is available in the format of Mathematica.
This model is largely based on the detailed model of the mammalian
circadian clock in the paper:
Jae Kyoung Kim and Daniel B. Forger (2012) "A mechanism for robust
circadian timekeeping via balanced stoichiometry", Molecular Systems
The original model is available from the ModelDB (Access code: