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CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)

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Accession:148646
" ... the investigation of AP backpropagation and its functional roles has greatly benefitted from computational models that use biophysically and morphologically accurate implementations. ..." This model entry recreates figures 2 and 4 from the paper illustrating how conductance densities of voltage gated channels (fig 2) and the timing of synaptic input with backpropagating action potentials (fig 4) affects membrane voltage trajectories.
Reference:
1 . Gasparini S,Migliore M (2015) Action Potential Backpropagation Encyclopedia of Computational Neuroscience, (Jaeger D:Jung R, ed. pp.133
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Action Potentials; Synaptic Integration;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I h;
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GaspariniMigliore2015
readme.html
distr.mod *
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3.mod *
nax.mod *
bAP.PNG
fixnseg.hoc *
geoc81462.hoc *
mosinit.hoc
springer-bAP.hoc
springer-bAPsyn.hoc
stdp.PNG
                            
/* Sets nseg in each section to an odd value
   so that its segments are no longer than 
     d_lambda x the AC length constant
   at frequency freq in that section.

   Be sure to specify your own Ra and cm before calling geom_nseg()

   To understand why this works, 
   and the advantages of using an odd value for nseg,
   see  Hines, M.L. and Carnevale, N.T.
        NEURON: a tool for neuroscientists.
        The Neuroscientist 7:123-135, 2001.
*/

// these are reasonable values for most models
freq = 100      // Hz, frequency at which AC length constant will be computed
d_lambda = 0.1

func lambda_f() { local i, x1, x2, d1, d2, lam
        if (n3d() < 2) {
                return 1e5*sqrt(diam/(4*PI*$1*Ra*cm))
        }
// above was too inaccurate with large variation in 3d diameter
// so now we use all 3-d points to get a better approximate lambda
        x1 = arc3d(0)
        d1 = diam3d(0)
        lam = 0
        for i=1, n3d()-1 {
                x2 = arc3d(i)
                d2 = diam3d(i)
                lam += (x2 - x1)/sqrt(d1 + d2)
                x1 = x2   d1 = d2
        }
        //  length of the section in units of lambda
        lam *= sqrt(2) * 1e-5*sqrt(4*PI*$1*Ra*cm)

        return L/lam
}

proc geom_nseg() {
  soma area(0.5) // make sure diam reflects 3d points
  forall { nseg = int((L/(d_lambda*lambda_f(freq))+0.9)/2)*2 + 1  }
}


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