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Using Strahler's analysis to reduce realistic models (Marasco et al, 2013)
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Accession:
149000
Building on our previous work (Marasco et al., (2012)), we present a general reduction method based on Strahler's analysis of neuron morphologies. We show that, without any fitting or tuning procedures, it is possible to map any morphologically and biophysically accurate neuron model into an equivalent reduced version. Using this method for Purkinje cells, we demonstrate how run times can be reduced up to 200-fold, while accurately taking into account the effects of arbitrarily located and activated synaptic inputs.
Reference:
1 .
Marasco A, Limongiello A, Migliore M (2013) Using Strahler's analysis to reduce up to 200-fold the run time of realistic neuron models.
Sci Rep
3
:2934
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Dendrite;
Brain Region(s)/Organism:
Hippocampus;
Cerebellum;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Cerebellum Purkinje GABA cell;
Channel(s):
I Na,t;
I T low threshold;
I K;
I Calcium;
Ca pump;
Gap Junctions:
Receptor(s):
AMPA;
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Active Dendrites;
Influence of Dendritic Geometry;
Detailed Neuronal Models;
Action Potentials;
Synaptic Integration;
Implementer(s):
Limongiello, Alessandro [alessandro.limongiello at unina.it];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
Cerebellum Purkinje GABA cell
;
AMPA
;
I Na,t
;
I T low threshold
;
I K
;
I Calcium
;
Ca pump
;
Glutamate
;
/
PurkReductionOnLine
morphologies
readme.txt
CaE.mod
*
Other models using CaE.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
CalciumP.mod
*
Other models using CalciumP.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
CaP.mod
*
Other models using CaP.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
CaP2.mod
*
Other models using CaP2.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
CaT.mod
*
Other models using CaT.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
K2.mod
*
Other models using K2.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
K22.mod
*
Other models using K22.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
K23.mod
*
Other models using K23.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
KA.mod
*
Other models using KA.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
KC.mod
*
Other models using KC.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
KC2.mod
*
Other models using KC2.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
KC3.mod
*
Other models using KC3.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
KD.mod
*
Other models using KD.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
Kdr.mod
*
Other models using Kdr.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
Kh.mod
*
Other models using Kh.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
Khh.mod
*
Other models using Khh.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
KM.mod
*
Other models using KM.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
Leak.mod
*
Other models using Leak.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
NaF.mod
*
Other models using NaF.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
NaP.mod
*
Other models using NaP.mod:
Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
pj.mod
clusterisingMethods.hoc
fixnseg.hoc
mergingMethods.hoc
mosinit.hoc
ranstream.hoc
*
Other models using ranstream.hoc:
Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
RedPurk.hoc
stimulation1.hoc
useful&InitProc.hoc
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