" ... A computational model,
which simulated molecular processes underlying long-term
synaptic facilitation (LTF) induction, predicted a rescue protocol of five pulses of 5-HT at non-uniform interstimulus
intervals that overcame the consequences of reduced CREB-binding protein (CBP) and restored LTF. ..."
Reference:
1 .
Liu RY, Zhang Y, Baxter DA, Smolen P, Cleary LJ, Byrne JH (2013) Deficit in long-term synaptic plasticity is rescued by a computationally predicted stimulus protocol. J Neurosci 33:6944-9 [PubMed]
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