Roles of essential kinases in induction of late hippocampal LTP (Smolen et al., 2006)

 Download zip file 
Help downloading and running models
Accession:149175
"… Convergence of multiple kinase activities to induce L-LTP helps to generate a threshold whereby the amount of L-LTP varies steeply with the number of brief (tetanic) electrical stimuli. The model simulates tetanic, -burst, pairing-induced, and chemical L-LTP, as well as L-LTP due to synaptic tagging. The model also simulates inhibition of L-LTP by inhibition of MAPK, CAMKII, PKA, or CAMKIV. The model predicts results of experiments to delineate mechanisms underlying L-LTP induction and expression. …"
Reference:
1 . Smolen P, Baxter DA, Byrne JH (2006) A model of the roles of essential kinases in the induction and expression of late long-term potentiation. Biophys J 90:2760-75 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: Java;
Model Concept(s): Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways; CREB;
Implementer(s): Byrne, John [john.h.byrne at uth.tmc.edu]; Smolen, Paul [paul.d.smolen at uth.tmc.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; NMDA; Glutamate;
 
/
Smolen_LTP_2006
readme.txt
smolenltp.java
                            
File not selected

<- Select file from this column.
Loading data, please wait...