A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)

 Download zip file 
Help downloading and running models
Accession:149739
This is a two-layer biophysical olfactory bulb (OB) network model to study cholinergic neuromodulation. Simulations show that nicotinic receptor activation sharpens mitral cell receptive field, while muscarinic receptor activation enhances network synchrony and gamma oscillations. This general model suggests that the roles of nicotinic and muscarinic receptors in OB are both distinct and complementary to one another, together regulating the effects of ascending cholinergic inputs on olfactory bulb transformations.
Reference:
1 . Li G, Cleland TA (2013) A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb. J Neurosci 33:3037-58 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,p; I L high threshold; I T low threshold; I A; I M; I h; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; I_Ks; I Cl, leak; I Ca,p;
Gap Junctions:
Receptor(s): Nicotinic; GabaA; Muscarinic; AMPA; NMDA;
Gene(s):
Transmitter(s): Acetylcholine;
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Sensory processing; Sensory coding; Neuromodulation; Olfaction;
Implementer(s): Li, Guoshi [guoshi_li at med.unc.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell; Nicotinic; GabaA; Muscarinic; AMPA; NMDA; I Na,p; I L high threshold; I T low threshold; I A; I M; I h; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; I_Ks; I Cl, leak; I Ca,p; Acetylcholine;
/
ACh_ModelDB
data
Input
Readme.txt
cadecay.mod *
cadecay2.mod *
Caint.mod *
Can.mod *
CaPN.mod *
CaT.mod *
GradeAMPA.mod *
GradeGABA.mod *
GradNMDA.mod *
hpg.mod *
kAmt.mod *
KCa.mod *
KDRmt.mod *
kfasttab.mod *
kM.mod *
KS.mod *
kslowtab.mod *
LCa.mod *
nafast.mod *
NaP.mod *
Naxn.mod *
Nicotin.mod *
nmdanet.mod *
OdorInput.mod *
Background.hoc
Connect.hoc
GC_def.hoc
GC_save.hoc *
GC_Stim.hoc
Input.hoc
MC_def.hoc
MC_save.hoc
MC_Stim.hoc
mod_func.c
mosinit.hoc
nrniv.exe.stackdump
OB.hoc
Parameter.hoc
PG_def.hoc
PG_save.hoc *
PG_Stim.hoc
SaveData.hoc
tabchannels.dat *
tabchannels.hoc
                            
Exception: STATUS_ACCESS_VIOLATION at eip=6D698668
eax=00000000 ebx=006BF640 ecx=00000000 edx=006C15A8 esi=00B3F270 edi=00000001
ebp=0022C8F8 esp=0022C8E0 program=c:\nrn71\bin\nrniv.exe, pid 3120, thread main
cs=001B ds=0023 es=0023 fs=003B gs=0000 ss=0023
Stack trace:
Frame     Function  Args
0022C8F8  6D698668  (00000002, 006BDC1C, 0022C928, 610E73A0)
0022C978  6D6A5BDD  (00000000, 00000000, 0022C9A8, 6D6CB611)
0022C988  6D69905F  (006C1578, 0000DF94, 0022C9A8, 00000000)
0022C9A8  6D6CB611  (6116B660, 00000000, 00000000, 00000001)
0022C9C8  6D6CB7A5  (00000002, 6116B600, 00000000, 6D7E13A6)
0022CCB8  6D5CDE33  (00000002, 6116B600, 006A0090, 00000000)
0022CCE8  004010BC  (00000002, 6116B600, 006A0090, 00000000)
0022CD98  610060D8  (00000000, 0022CDD0, 61005450, 0022CDD0)
61005450  61004416  (0000009C, A02404C7, E8611021, FFFFFF48)
     38 [main] nrniv 3120 _cygtls::handle_exceptions: Error while dumping state (probably corrupted stack)

Loading data, please wait...